Margarita Alvira, Susan J. Quinn, Anna Aviñó, Donald Fitzmaurice, Ramon Eritja
Institute for Research in Biomedicine
(IRB Barcelona), Institute for Advanced Chemistry of Catalonia
(IQAC), Spanish Research Council (CSIC), Networking Centre on Bioengineering,
Biomaterials and Nanomedicine (CIBER-BBN), Josep Samitier 1-
5, E-08028 Barcelona, Spain.
The preparation of oligonucleotide conjugates carrying viologen and fluorescein is described. Reaction of the
appropriate carboxyl derivatives with oligonucleotides carrying aliphatic amino groups gave the desired compounds. A
simple method for the introduction of the amino group at the 5’-end of the oligonucleotides is reported.