The Open Parasitology Journal




ISSN: 1874-4214 ― Volume 7, 2019

C-Kit Ligand Promotes Mast Cell Infection by Toxoplasma gondii


The Open Parasitology Journal , 2008, 2: 43-50

Mohamed Bidri, Marc Conti, Naïma Hanoun, René Lai Kuen, Frédéric Feger, Zacharie Taoufiq, Michel Arock, Dominique Mazier , Ioannis Vouldoukis

INSERM UMR S511, Immunobiologie Cellulaire et Moléculaire des Infections Parasitaires, Université Pierre et Marie Curie-Paris6, CHU-Pitié-Salpêtrière, 91 bd de l’Hôpital, 75013 Paris, France.

Electronic publication date 19/5/2008
[DOI: 10.2174/1874421400802010043]

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Abstract:

Biological functions of mast cells include a functional role in innate immunity against parasitic infections. Here, we demonstrated that mast cells could also play a role in the anti-microbial defenses regulation and might participate as a parasite reservoir. We observed that Toxoplasma gondii infected massively in vitro mouse bone marrow derived mast cells (BMMC), a mucosal mast cell (MMC) phenotype, followed by substantial cell lysis. This induced release of 􀀂- hexosaminidase, but not of preformed or neosynthesized TNF-􀀁. Culturing MMC in the presence of recombinant mouse stem cell factor (c-kit ligand) led to their maturation into connective tissue-like mast cells (CTMC), which T. gondii was able to adhere on and to infect more. T. gondii infection did not induce release of 􀀂-hexosaminidase and serotonin from BMMC. These results demonstrated that mast cells interact with T. gondii and are massively infected, especially after their maturation by c-kit ligand.


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