Departamento de Microbiologia
Geral, Instituto de Microbiologia Prof. Paulo de Góes (IMPPG), Centro
de Ciências da Saúde (CCS) Universidade Federal do Rio de Janeiro
(UFRJ), Bloco I, Ilha do Fundão, 21941-590 Rio de Janeiro, RJ, Brazil.
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Neutral monohexosylceramides (CMHs) globosides (globotriasyl ceramides), other glycosphingolipids (GSLs)
and more complex structures such as glycoinositol-phospholipids(GIPLs) and glycosyl phosphatidylinositol (GPI) anchors
have been described in several members of the trypanosomatid family. These highly bioactive molecules are not only
components of biological structures but also participants in host-parasite interactions such as macrophage invasion, antigenic
presentation and signal transduction. Glycolipid structures have been studied using mass spectrometry (MS).This
review describes a wide range of glycoconjugates with unique and complex structures that are present in several trypanosomatid
species. Their structures are described in the context of their biological significance.