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Oral cancer is the 8th most common cancer in males and the 15th most common in females in the United States.
Each year, it affects approximately 22,000 Americans and results in approximately 5300 deaths. The five-year survival
rate of oral cancer remains low (53% to 60%) for the past three decades and delayed diagnosis has been suggested to be
one of the major reasons. The detection and diagnosis of oral cancer is currently based on clinical visual examination and
histopathological evaluation of the biopsy material. In responding to the need for early detection of oral cancer, several
diagnostic adjuncts have been developed over the years. The purpose of this article is to review the current knowledge
about the commercially available diagnostic adjuncts as well as to review the research on the development of the
promising tools for the early detection of oral cancer.