Prostate cancer is the most commonly diagnosed malignancy and the leading cause of cancer-related mortality
among men in Australia and the USA. A key turning point in the course of cancer progression is the development of metastatic
potential as most prostate cancer related deaths are not due to the primary tumour, but rather to metastases. A better
understanding of molecular mechanisms that underlie the process of prostate cancer metastasis to lymph nodes will
most likely result in improved therapeutic options for patients and thus help reduce the burden of the disease. This review
will focus on the current knowledge of molecular mechanisms that regulate the spread of prostate cancer to lymph nodes
and potential new targets for therapy.