The Open Pediatric Medicine Journal




ISSN: 1874-3099 ― Volume 9, 2019

Sacrosidase Trial in Chronic Nonspecific Diarrhea in Children


The Open Pediatric Medicine Journal, 2008, 2: 35-38

Riad M. Rahhal, Warren P. Bishop

University of Iowa Children's Hospital, Department of Pediatrics, Division of Gastroenterology, 200 Hawkins Dr, 2868 JPP, Iowa City, Iowa 52242, USA.

Electronic publication date 15/10/2008
[DOI: 10.2174/1874309900802010035]

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Abstract:

Chronic nonspecific diarrhea in children, or toddler’s diarrhea, is a frequently encountered entity in pediatric clinical practice. This disorder remains poorly understood. Suggested etiologies include malabsorption, dietary intake and motility abnormalities. We investigated the use of sacrosidase (a yeast sucrase supplement) in children with toddler’s diarrhea. The study outcome was clinical response to sacrosidase supplementation. Children, 1-6 years of age, with toddler’s diarrhea were enrolled in an open prospective trial. Stooling patterns were obtained at baseline and while on supplementation. Twelve patients were enrolled out of 40 patients who presented with chronic diarrhea. Eight patients did not respond to standard diet changes and were entered into the trial. With supplementation, 4 out of the 8 patients responded clinically with a decrease in mean daily stool frequency and an improvement in the mean daily stool consistency. Sacrosidase supplementation demonstrated a potential benefit in a subset of children with toddler’s diarrhea. Response to sacrosidase may suggest excessive sucrose intake or unrecognized partial or complete sucrase deficiency in some children with toddler’s diarrhea.


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