Pharmaceutical Crops




(Discontinued)

ISSN: 2210-2906 ― Volume 6, 2017

Simultaneous HPLC Determination of Costunolide and Dehydrocostuslactone in Xin-ke-shu Preparations


Pharmaceutical Crops, 2011, 2: 74-78

Shu Dong, Yue-tao Liu, Jing-bo Peng, Hong-mei Jia, Zhong-mei Zou, Chang-yuan Yu

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China.

Electronic publication date 2/12/2011
[DOI: 10.2174/2210290601102010074]




Abstract:

The objective of this study is to establish a quantitative method for simultaneous determination of costunolide and dehydrocostuslactone in Xin-ke-shu preparations. The HPLC quantitative analysis was established on a Hypersil BDS column (100x 4.6 mm, 2.4 μm, Thermo) with UV detection at 225 nm. The mobile phase was water and methanol (30:70, v/v), and used at a flow rate at 0.5 mL·min- 1 . The established method showed a good linearity (R2 > 0.9999) over the investigated concentration ranges (0.07-2.80 μg), good inter-day and intra-day precisions (less than 3%) and good recoveries (from 99.82% to 99.98%) for both target compounds. The method was found to be suitable for simultaneous determination of costunolide and dehydrocostuslactone in Xin-ke-shu preparations and can be used as a comprehensive approach to the previous reported quality control of Xin-ke-shu preparations.


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