Pharmaceutical Crops




(Discontinued)

ISSN: 2210-2906 ― Volume 6, 2017

Protective Effects of Mangifera indica L. Extract Against Lipofundininduced Oxidative Stress in Rats


Pharmaceutical Crops, 2012, 3: 94-98

Livan Delgado Roche, Ángela Fraga Pérez

Center of Studies for Research and Biological Evaluations, Pharmacy and Food Sciences College, University of Havana, Cuba.

Electronic publication date 20/4/2012
[DOI: 10.2174/2210290601203010094]

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Abstract:

Lipofundin is a lipid rich emulsion used in parenteral nutrition. It is known that Lipofundin induces an oxidative stress state characterized by an increase of lipid peroxidation and a dramatic depletion of antioxidants. The aim of the present study was to evaluate the effects of an aqueous extract of Mangifera indica L., on Lipofundin-induced oxidative stress. Male Sprague Dawley rats were treated orally with 200 mg/kg of Vimang®, followed by an intravenous dose of 2 mL/kg Lipofundin, daily, for 8 days. Selected oxidative stress biomarkers were then measured spectrophotometrically. The results showed that Vimang® produced significant (p<0.05) reduction of malondialdehyde, total hydroperoxides and advanced oxidation protein products, while the activities of superoxide dismutase and catalase were positively modulated. A significant (p<0.05) reduction of peroxidation potential and a preservation of glutathione and total antioxidant status was also observed. Our data demonstrated that Vimang® protects against Lipofundin-induced oxidative stress, which is an important finding that further reinforces the antioxidant properties of this natural product.


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