Lipofundin is a lipid rich emulsion used in parenteral nutrition. It is known that Lipofundin induces an oxidative
stress state characterized by an increase of lipid peroxidation and a dramatic depletion of antioxidants. The aim of the
present study was to evaluate the effects of an aqueous extract of Mangifera indica L., on Lipofundin-induced oxidative
stress. Male Sprague Dawley rats were treated orally with 200 mg/kg of Vimang®, followed by an intravenous dose of 2
mL/kg Lipofundin, daily, for 8 days. Selected oxidative stress biomarkers were then measured spectrophotometrically.
The results showed that Vimang® produced significant (p<0.05) reduction of malondialdehyde, total hydroperoxides and
advanced oxidation protein products, while the activities of superoxide dismutase and catalase were positively modulated.
A significant (p<0.05) reduction of peroxidation potential and a preservation of glutathione and total antioxidant status
was also observed. Our data demonstrated that Vimang® protects against Lipofundin-induced oxidative stress, which is
an important finding that further reinforces the antioxidant properties of this natural product.