1 Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India
2 Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Sahranpur-247341 UP, India
Anti-angiogenic therapy can produce transient regression in tumor in case of Glioblastoma (GBM); however, no prolongation of patient survival rate had so far been achieved.
To address this problem, an effort was made to design and characterize a temozolomide loaded nanosystem for targeting the tumor vasculature in the brain using polymeric nanoparticles. It included the formation of Temozolomide (TMZ) loaded Solid-Lipid Nanoparticles (SLNs) and their conjugation with polysorbate-80 (P-80) which enhanced the penetration of drug to blood-brain barrier resulting in the enhancement of pro-apoptotic activity.
Conjugating nanoparticles with a tumor-penetrating polymer (P-80) further enhanced the therapeutic efficacy of the drug.
The animal studies indicated the enhanced potential of the developed system in the effective treatment of glioblastoma.
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