In this study the effects of different Leptin concentrations on the blood pressure and heart rate in
vivo in anesthetized rabbits were studied.
Sixty Rabbits were divided into two groups, first group received Leptin intra-venously and other group received
Leptin intra-arterially. Blood pressure and heart rate in were recorded before and after administration of Leptin.
A significant increase in mean arterial blood pressure (MABP) was seen after an intra-arterial injection of 3, 5
and 7 µg/kg of Leptin. This increase in MABP was monitored for different durations 10, 20 and 30 minutes after the infusion
of each Leptin concentrations. The trend of the increase in MABP with time was demonstrated with all three concentrations.
Intra-venous infusion of Leptin caused a significant decrease in MABP after 10 minutes as well as after 20 and
30 minutes, with all three concentrations (3, 5, and 7 µg/Kg). Heart rate (HR) was not changed significantly at the end of
30 min of infusion.
this in vivo study demonstrated that intra-venous Leptin infusion has a different effect on the MABP compared
with intra-arterial infusion and this difference might be due to the site of action of Leptin.
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