The Open Conference Proceedings Journal

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ISSN: 2210-2892 ― Volume 10, 2019

Anti-fibrotic Effects of Reserpine on Lung Fibrosis: Stem Cells in the Pathogenesis of Pneumofibrosis

The Open Conference Proceedings Journal, 2013, 4: 31-46

E. G. Skurikhin, E. S. Khmelevskaya, O. V. Pershina, N. N. Ermakova, V. A. Krupin, L. A. Ermolaeva, V. D. Yakushina, A. M. Reztsova, V. M. Reztsova, I. E. Stepanova, A. M. Dygai

Laboratory of Pathological Physiology and Experimental Therapy (supervisor – acad. RAMS A.M. Dygai), Institute of Pharmacology of RAMS SD (dir. – acad. RAMS A.M. Dygai), Lenin Street, 3, Tomsk, 634028, Russia.

Electronic publication date 19/9/2013
[DOI: 10.2174/2210289201304010031]

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In this study was found that inflammation in interstitial lung tissue of mice C57Bl/6 after intratracheal injection of the bleomycin is accompanied by the increase of the bone marrow and circulating blood cells with the phenotype (CD3, CD45R (B220), Ly6C, Ly6G (Gr1), CD11b (Mac1), TER-119), Sca-1+, c-Kit+, CD34– (hematopoietic stem cells (HSCs)) and hematopoietic progenitor cells (granulocyte-erythroid-macrophage-megakaryocytic (CFU-GEMM) and granulocyte precursors (CFU-G)). These results demonstrate that the intraperitoneal reserpine injection reduces alveolar interstitium and alveolar passages infiltration by inflammatory cells and prevents the connective tissue growth in the lung parenchyma. Supposedly, the reserpine anti-inflammatory effect is caused by the reduced activity of the bone marrow HSCs differentiation in CFU-G, the decrease of circulating HSCs and progenitor hematopoietic cells and the violation of their migration in bleomycin-treated lungs. These data suggest the decrease caused by the reserpine in deposition of collagen fibers in the lung's parenchyma associated with the decrease in the inflow of multipotent mesenchymal stromal cells (MSCs) and fibroblast progenitor bone marrow-derived cells to lungs. Thus, reserpine violates the MSCs differentiation into fibroblast-like cells.

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