Peptides are becoming more of interest in the area of drug discovery and delivery . Some peptides have already reached the
global market sales. Their different mechanism of action  compared to the conventional antibiotics made them prominent
leads for searching novel molecules against resistant pathogens. More drug discovery companies are interested in peptides as
therapeutic lead molecules. Solving the problems of peptides for their short half-life and their delivery problems is the current
challenge. In this context, we designed some small peptides as antibacterial, antitubercular and HIV-1 protease enzyme
inhibitors. The synthesis of these small peptides achieved by solution phase peptide synthesis, their structural characterisation
and their therapeutic activities are discussed.