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Rhizomes of Zingiber zerumbet that belonging to genus Zingiberaceae have been used in traditional medicine, especially
among the Asian community. This study aimed to investigate antioxidant potential of ethyl acetate extract of Z. zerumbet.
Identification of extract compound rhizomes of Z. zerumbet was carried out by Gas Chromatography–Mass Spectrometry (GCMS).
The GC-MS analysis revealed 12 compounds and the major constituent is Zerumbone (51.57%). Determination of safe
concentration Z. zerumbet towards rat red blood cells (RBCs) has been done and showed that incubated RBCs at a
concentration 50 μg/ml, 25 μg/ml, 12.5 μg/ml and 6.25 μg/ml of ethyl acetate extract of Z. zerumbet for 1 hour not cause
significant differences in hemolysis and the level of malondialdehyde (MDA) compared to the control group, NaCl. The
antioxidant properties of ethyl acetate extract of Z. zerumbet were compared using in vitro antioxidant methods such as DPPH
radical scavenging and FRAP assays while the amount of major phenolic compounds were determined by spectrophotometric
methods. The results showed that ethyl acetate extract of Z. zerumbet exhibited antioxidant and radical-scavenging activities at
different magnitudes of potency although the effects were small to that BHT. The results obtained in the present study indicates
that the rhizomes of Z. zerumbet at concentration range 6.25 μg/ml-50 μg/ml are a potential source of natural antioxidants on