Curcuminoids has been reported to possess a variety of biological and pharmacological applications, but its efficacy has been
limited by its poor bioavailability and unstable structure. In this study, 52 curcumin related diarylpentanoid analogues were
designed and synthesized, and their pre-screening inhibition against nitric oxide (NO) suppression in interferon-gamma (IFN-
γ)/ lipopolisaccharide (LPS)- activated RAW 264.7 cells was evaluated. The structures of this new series of diarylpentanoids,
consisting of mono-carbonyl and two consecutive methylene moieties in the middle linker, were established using 1H and 13C
NMR spectrometry and mass spectral analyses. Most of the compounds showed good activity with more than 50% inhibition.
The present result might contribute to the development of improved anti-inflammation agents.