Triterpene acid compounds are potent anti-tumor agents showing a remarkable cytotoxicity on various tumor cells. Betulinic
acid (BA), as the main constituents of Melaluca cajiput sp. bark is one of the promising compound that also has anti-retrovial,
anti-malaria, anti HIV and anti-inflammatory activities. Based on theirs therapeutic properties of peptide based on betulinic
acid, we became interested to synthesized the betulinic acid peptides. We herein report the synthesis of several natural amino
acid-BA peptides using standard coupling protocols (HOBt, HBTU, DiPEA). In addition, enantiopure cyclohexene silyl ether-
BA peptide, was successfully synthesized. The result of the biological evaluation are expected to improve the general
understanding of BA structure.