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A large number of biologically active natural products contain indole as a part of their structures, Numerous
bis(indolyl)methane have been isolated from several terrestrial and marine plants, possessing a variety of biological activities.
Nevertheless, the discovery of potent anti-carcinogenic bis(indolyl)methane have attracted a major attention of researchers.
Bis(indolyl)methane is the most active cruciferous substance for promoting beneficial estrogen metabolism in women and men,
and may have useful application as breast cancer preventive agent. Different indoles were reacted with different aldehydes in
the presence of equimolar amount of sodium thiosulfate in PEG 400 yielded corresponding substituted Bis(indolyl)methanes in
good yields. We tested same reaction with different solvents but we found that the PEG gave the desire reaction yield in short
reaction time. This is a facile, environmentally friendly and cheap method towards the synthesis of an important class of
organic compounds. All synthesized compounds are characterized by art of spectroscopy.