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The tiger’s milk mushroom, Lignosus rhinocerus (Cooke) Ryvarden, has long history of use as natural remedies for ailments by
the local and indigenous communities in Malaysia. From the ethnobotanical perspective, only the sclerotia were claimed to
have medicinal values; however, the supply of sclerotia from the wild is limited. Solid-substrate cultivation of the sclerotia of L.
rhinocerus takes a long time and the yield is inconsistent. Alternatively, the mycelia can be produced in a shorter time through
liquid fermentation. In the present study, bioactivities of extracts of the sclerotia as well as mycelia and culture broth of L.
rhinocerus were assessed. Extracts of mycelia and culture broth of L. rhinocerus exhibited significantly higher antioxidant
capacities as measured by the radical scavenging, reducing capacity and metal chelating assays. On the other hand, extracts of
the sclerotia displayed stronger growth inhibitory effect against various cancer cell lines. The nature of potential bioactive
components responsible for the in vitro antioxidant and cytotoxic activities was unravelled based on the results of
chromatographic analysis of extracts. The occurrence of bioactive components in L. rhinocerus varied according to cultivation
techniques and mushroom developmental stages. The mycelia and culture broth of L. rhinocerus might emerge as alternative
source of nutraceuticals depending on the desired bioactive components.