2 Medizinische Klinik and Poliklinik II, University of Wuerzburg, Germany
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. Recently several novel autoantibodies against a variety of specific nuclear pore proteins have been described, including the nucleoporin p62. In this paper we evaluate anti-nucleoporin p62 antibodies by western blot analysis in 25 systemic lupus erythematosus patients. Six patients showed antibodies directed against nucleoporin p62. Our data indicate that p62 antibodies could be a useful additional marker in SLE.
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* Address correspondence to this author at the Haematology Department, Queen Cancer Centre of Oncology and Haematology, Castle Road, Cottingham, HU16 5JQ, UK; Tel: (44) 01482 461291; Fax: (44) 01482 607739; E-mail: Doris.Kraemer@hey.nhs.uk