The Open Rheumatology Journal

ISSN: 1874-3129 ― Volume 14, 2020

Melatonin and Its Day and Night Rhythm of Alterations in Familial Mediterranean Fever: A Brief Research Letter

Ugur Musabak*, 1, Guldem Kilciler2, Ahmet Uygun 2, Murat Kantarcıoglu 2, Zulfukar Polat 2, Rahsan I Sagkan 1, Sait Bagci 2
1 Department of Immunology, Gulhane Military Medical Academy and School of Medicine, 06018 Etlik, Ankara, Turkey
2 Department of Gastroenterology, Gulhane Military Medical Academy and School of Medicine, 06018 Etlik, Ankara, Turkey



The pineal hormone melatonin plays a crucial role in immunomodulation, mainly by effecting T cells. The aims of the present study were to compare the melatonin levels in patients with Familial Mediterranean Fever (FMF) and healthy controls and to find out if it associates with interferon(IFN)γ and interleukin(IL)-10.

Materials and Methodology:

Twenty five patients with FMF and 16 healthy donors were enrolled into the study. Melatonin, IFN γ and IL-10 measurements were assayed by using enzyme immunoassay (EIA) method.


Serum melatonin levels at 03.30 am in both patients during attack-free phase and healthy controls were significantly higher than those levels of corresponding groups measured at 10.00 am. The melatonin levels at 03.30 and 10.00 am in patients during attack-free phase were higher than those levels measured in healthy controls at the same time points. IFNγ and IL-10 did not show any day and night rhythm in both patients and healthy controls. In addition, there was no association among day and night levels of melatonin, IFNγ and IL-10.


We conclude that melatonin may play a role in FMF pathogenesis. However, its modulatory effect on immune response most likely does not depend on T cells. Further comprehensive studies should be performed in order to reveal the role of melatonin in the pathogenesis of this disease.

Keywords: Familial Mediterranean fever, melatonin, interferon, interleukin..

Article Information

Identifiers and Pagination:

Year: 2011
Volume: 5
First Page: 13
Last Page: 17
Publisher Id: TORJ-5-13
DOI: 10.2174/1874312901105010013

Article History:

Received Date: 2/5/2010
Revision Received Date: 12/9/2010
Acceptance Date: 14/9/2010
Electronic publication date: 4/2/2011
Collection year: 2011

© Musabak et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Immunology, Gulhane Military Medical Academy and School of Medicine, 06018 Etlik, Ankara, Turkey; Tel: +90 312 304 43 41; Fax: +90 312 304 20 40; E-mail:

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