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Dental pulp stem cells (DPSCs) from permanent teeth and stem cells from human exfoliated deciduous teeth
(SHED) have attracted tremendous interest recently by playing a major role in tissue engineering and regenerative
medicine. However, since stem cell technology is still in its infancy, interdisciplinary cooperation between medicine, basic
biological research, nanotechnology and materials science is needed to achieve successful clinical applications. Similar
to mesenchymal stem cells, DPSCs and SHED can undergo self-renewal and have multipotent differentiation ability, but
unlike other sources of stem cells such as embryonic stem cells, which involves the destruction of human embryo, DPSCs
and SHED have limited ethical concerns as they are readily and easily accessible, non-invasive and disposed off naturally.
Not only DPSCs and SHED can be used for cell based therapies and bio-artificial tissue constructs but also made to
differentiate into other cell types. Here, we discuss on definitions, opportunities, advantages and limitations of DPSCs and
SHED in tissue engineering and regenerative medicine.