Marjolin's ulcer is a malignant tumor developing in the chronic skin lesion (e.g. burn scar, vaccination scar,
non-healing wound). We report two histological different cases: ulcerated squamous cell carcinoma growing in the burn
scar and basal cell carcinoma arising in the vaccination scar. We present clinically-oriented literature review and
management recommendations. In general all non-healing chronic wounds should be surgically closed and large open
wounds must not be left for secondary intention healing to prevent delayed malignant transformation. All burn scars
should be monitored by appropriately informed patient and family physician. All suspected masses within chronic
wounds/burn scars should be promptly biopsied. If Marjolin's ulcer diagnosis is established, wide local excision
comprising fascia should be performed as well as careful clinical assessment of regional lymph nodes.