Autonomic Nervous System Activity in Patients with Lower Urinary Tract
Symptoms Secondary to Benign Prostatic Hyperplasia Estimated by Heart
Kajetan Juszczak*, 1, 2, Marcel Mazur1, Marek Wyczółkowski2, Marek Filipek3, Piotr J. Thor1
1 Department of Pathophysiology, Medical Collage, Jagiellonian University, Cracow, Poland
2 Department of Urology, Rydygier Memorial Hospital, Cracow, Poland
3 Department of Urology, John Paul II Hospital, Grodzisk Mazowiecki, Poland
Aging induces autonomic nervous system (ANS) dysfunction with increased sympathetic drive.
Benign Prostatic Hyperplasia (BPH) is responsible for lower urinary tract symptoms (LUTS), and its pathogenesis is complex.
Exemplified by previous studies, the probably cause of BPH and secondary LUTS is due to the overly active sympathetic
ANS resulting from aging.
The aim of our study was to estimate the ANS activity in BPH patients with LUTS using frequency domain
analysis parameters of heart rate variability (HRV). Additionally, the relationship of ANS activity to the subjective measures
of LUTS, and the objective measures of BPH, as well as the biochemical and biometrical variables, were investigated.
Material & methods:
The study was performed on 30 men with LUTS secondary to BPH. The cohort of patients was
asked to complete IPSS and quality of life questionnaires. We performed biometrical, biochemical measurements and
urological estimations. Additionally, a serum sample was obtained for Prostate Specific Antigen and its derivatives analysis.
ANS activity was assessed by HRV measurements in resting conditions, after simulation with deep breathing and by
the tilt up test. In the HRV recording, frequency domain analysis parameters were calculated according to fast Fourier
transformation and the correlation for ANS activity parameters vs BPH variables were analyzed. The following HRV parameters
were taken into consideration: VLF (power of very low frequency), LF (power of low frequency), LFnu (LF
power in normalized units), HF (power of high frequency), HFnu (HF power in normalized), LF/HFnu (normalized ratio
of LF power to HF power), PSD (total power of spectrum of the RR variability).
All participants (mean age 65 ± 7 years) presented moderate LUTS (IPSS = 14 pts.; QofL = 3 pts.) with Qave.= 7,4 ml/sec. and PVR = 48 ± 45 ml. Normalized values of LF and HF were 60.86 ± 18.96 [%] and 39.14 ± 18.96 [%], respectively. VLF - 238.75 ± 214.96 [ms2]. LF/HF ratio and its normalized value were 2.97 ± 3.04  and 1.57 ± 1.40 , respectively. In response to deep breathing, significant increases of LF, LFnu, LF/HF, LF/HFnu and total power of HRV spectrum and a decrease of HFnu were observed. The E/I ratio was 1,12 ± 0,08. During the tilt up test, VLF, LFnu, LF/HF, and LF/HFnu were increased, while HFnu decreased. The 30/15 ratio was 0,98 ± 0,05. The observed strong correlations are as follows: 1) between prostate enlargement and HFnu and LFnu power; 2) between total PSA level and LFnu, HF, HFnu; 3) between free/total PSA ratio and LF/HFnu; 4) between PSA density of the transition zone and HF; 5) between plasma noradrenalin level and HF; 6) between age and LFnu, HFnu, LF/HF and LF/HFnu; 7) between plasma adrenaline level and prostate enlargement: prostate length and transition zone height.
These results demonstrate the sympathetic overactivity of ANS at rest in patients with BPH and LUTS. It is
also suggested that in the pathophysiology of BPH, the heighten activity of the sympathetic ANS, and parasympathetic
drive are important.
Received Date: 10/10/2008 Revision Received Date: 19/11/2008 Acceptance Date: 25/11/2008 Electronic publication date: 15/12/2008
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