The Open Virology Journal


ISSN: 1874-3579 ― Volume 15, 2021

Effect of Immunomodulating Adjuvant Dzherelo (Immunoxel) in HIV Infected Patients Receiving Standard Antiretroviral Therapy

Lyudmila G Nikolaeva1, Tatiana V Maystat1, Yuri L Volyanskii2, Volodymyr S Pylypchuk3, Valery M Frolov4, Galyna A Kutsyna*, 4
1 Kharkov Regional AIDS Prophylaxis and Prevention Center, Kharkov Medical Academy of Postgraduate Education, 6 Bor’by Street, Kharkov 61044, Ukraine
2 I.I. Mechnikov Institute of Microbiology and Immunology, Kharkov 61057, Ukraine
3 Ekomed LLC., Prospect Pravdy 80-A, Kiev 04208, Ukraine
4 Luhansk State Medical University and Regional AIDS Center, Luhansk 91045, Ukraine


Open-label, matched-case, comparative trial was conducted in 40 HIV-infected patients to evaluate the adjunct effect of Dzherelo (Immunoxel) on immune and viral parameters. Arm A (n=20) received anti-retroviral therapy (ART) consisting of zidovudine, lamivudine, and efavirenz and arm B (n=20) received ART with Dzherelo. After 2 months total T-lymphocytes increased in ART recipients from 664 to 819 cells/μl (P=0.06), whereas in Dzherelo recipients they rose from 595 to 785(P=0.03). The CD4 T-cells expanded by 57.3% (218 to 343; P=0.002) in the ART arm and by 93.5% (184 to 356; P=0.004) in the Dzherelo arm. The accrual in absolute and relative number of CD8+ lymphocytes in ART and in the Dzherelo recipients was 43.2% (2.7%) and 50.4% (-0.5%) respectively. The CD4/CD8 ratio in Dzherelo recipients increased from 1.495 to 1.940 (P=0.03) but insignificant in the control: 1.418 to 1.613 (P=0.14). Activated CD3+ HLADR+ T-cells increased from 209 to 264 (P=0.02) and from 161 to 348 (P=0.0007) in ART and Dzherelo recipients respectively. No changes in CD20+ B-lymphocytes were seen in the control, but in Dzherelo patients they declined from 509 to 333 (P=0.00008). The proportion of CD3- CD16+CD56+ NK cells was not affected by ART but addition of Dzherelo raised NK cells from 11.2% to 17.1% (P=0.0001). About three-quarters (14/19) of patients on ART displayed decrease in viral load (1718 to 1419 copies/ml; P=0.008), while 95% of patients on Dzherelo had a decrease (1793 to 1368; P=0.001). Dzherelo has a favorable effect on the immune status and viral burden when given as an immunomodulating adjunct to ART.

Keywords: AIDS, antiviral, HAART, herbal, immunotherapy, phytotherapy..

Article Information

Identifiers and Pagination:

Year: 2009
Volume: 3
First Page: 31
Last Page: 36
Publisher Id: TOVJ-3-31
DOI: 10.2174/1874357900903010031

Article History:

Received Date: 19/2/2009
Revision Received Date: 19/3/2009
Acceptance Date: 26/3/2009
Electronic publication date: 5/5/2009
Collection year: 2009

© Nikolaeva et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: // which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Infectious Diseases and Epidemiology, Luhansk State Medical University, Luhansk 91045, Ukraine; Tel/Fax: +38-057-392-09-08; E-mail:

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