1 Department of Medical Microbiology, University of Zimbabwe, Harare, Zimbabwe
2 Division of Medical Virology, University of Cape Town, Cape Town, South Africa
HIV/AIDS is an important public health problem globally. An affordable, easy-to-deliver and protective HIV
vaccine is therefore required to curb the pandemic from spreading further. Recombinant Salmonella bacteria can be
harnessed to vector HIV antigens or DNA vaccines to the immune system for induction of specific protective immunity.
These are capable of activating the innate, humoral and cellular immune responses at both mucosal and systemic
compartments. Several studies have already demonstrated the utility of live recombinant Salmonella in delivering
expressed foreign antigens as well as DNA vaccines to the host immune system. This review gives an overview of the
studies in which recombinant Salmonella bacteria were used to vector HIV/AIDS antigens and DNA vaccines. Most of
the recombinant Salmonella-based HIV/AIDS vaccines developed so far have only been tested in animals (mainly mice)
and are yet to reach human trials.
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* Address correspondence to this author at the Department of Medical
Microbiology, University of Zimbabwe, P O Box A178, Avondale, Harare,
Zimbabwe; Tel: +263-4-791-631, Ext. 2419; Fax: +263-4-792-245;