Equine Herpes virus-1 (EHV-1) is one of the most common respiratory pathogens of the horse. EHV-1 induces
several clinical signs of disease ranging in severity, from mild respiratory distress to abortion in pregnant mares, neonatal
foal death and neuropathogenic disorders. This review details some aspects of EHV-1 biology, its life cycle and pathogenicity
in the natural host. Protective immunity stimulated by natural EHV-1 infection, which is short lived and depends
of both humoral and cellular immune responses, will also be treated here. Vaccination remains today one of the best options
to fight EHV-1 infection and several different strategies of vaccination that have been investigated and developed
over the past decades will be presented in this report.