The integuments of five toads (Rhinella icterica) were histologically analyzed and two of them exhibited brownish encapsulated subcutaneous mass of the integument. Fungal elements involved by multinucleated histiocytic gi-ant cells were restrict to the hypodermis. This granulomatous inflammatory process showed an extracellular matrix rich in a hyaluronic acid. Moreover, these areas were surrounded by fibrous connective tissue, where collagenous fibers pre-dominate. Since chromomycosis was previously reported in a bufonid from Amazon region and this work was first in Southeast from Brazil, it is possible that this disease may be spread to other Brazilian regions.