Vascular Disease Prevention




(Discontinued)

ISSN: 1567-2700 ― Volume 7, 2013

Cerebrovascular Disease and its Relationship to Other Vascular Beds: A Comprehensive Review of the Literature


Vascular Disease Prevention, 2009, 6: 1-8

Julia Slark, Pankaj Sharma

Imperial College Cerebrovascular Research Unit (ICCRU), Hammersmith Hospitals, Imperial College London, Fulham Palace Rd, London W6 8RF, UK.

Electronic publication date 6/March/2009
[DOI: 10.2174/1567270001006010001]




Abstract:

Atherothrombosis, ischaemic heart disease (IHD), cerebrovascular disease (CVD) and peripheral arterial disease (PAD) are a major cause of mortality and are predicted to be the leading cause of death world-wide by 2020.

It is now recognised that CVD is part of a family of atherothrombotic diseases such as PAD and IHD. However, despite receiving contemporary evidence-based preventative drug therapy, patients with established arterial disease and those with multiple risk factors for atherothrombosis both experience high cardiovascular (CV) event rates with a 4.7% yearly rate of hard events. People with symptomatic atherosclerosis in 1 vascular bed are at a higher risk of subsequent events in other beds, e.g. patients who suffer a stroke are at a high risk of going on to suffer a coronary event, with a 10 year CV event risk of 42.8%. These findings support the need for increased awareness among physicians and patients for the amount of vascular cross-risk that is related to the overlap between the various beds of atherothrombosis.

Atherothrombosis in stroke patients should be considered as a global arterial disease. We present a systematic review of the literature relating to the risk of non-cerebral (especially sub-clinical) atherothrombotic events in ischaemic stroke patients.


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