Preeclampsia is a major cause of maternal and perinatal mortality. Although preeclampsia may be caused by
several factors, endothelial cell dysfunction has been proposed as the main pathophysiological cause. Dysfunctional endothelium
in the uteroplacental circulation not only increases peripheral vascular resistance, but also affects generalized
vasoconstriction via humoral factors released from the placenta. A standard method for predicting and preventing
preeclampsia has yet to be developed; however, the analysis of a combination of biochemical markers, particularly markers
related to vascular dysfunction, may enhance our ability to predict and prevent preeclampsia in the near future.