M. Rocha, R. García-Bou, N. Enguix, A. Hernández-Mijares, J.V. Esplugues, V.M. Víctor
Fundación Hospital Universitario
Doctor Peset, Servicio de Endocrinología, Avda Gaspar Aguilar 90,
46017, Valencia, Spain and Departamento de Farmacología. Facultad de
Medicina. Universitat de Valencia, Avenida Blasco Ibáñez 15-17, 46010
Mitochondria play an important role in controlling the bioenergetic status of cells in physiological conditions.
Consequently, mitochondrial dysfunction leads to a range of human vascular diseases in humans. Although the molecular
mechanisms responsible for mitochondria-mediated disease processes are not altogether clear, oxidative stress appears to
be closely linked to the subsequent increase in the amount of free radicals. Accordingly, strategies for the targeted delivery
of antioxidants to mitochondria are being developed. In this review, we shall briefly discuss the metabolism of cellular
reactive oxygen species and its role in pathophysiology, currently available antioxidants and possible reasons for their ineffectiveness
in ameliorating oxidative stress-mediated diseases, and recent developments in mitochondria-targeted antioxidants
(in particular mitochondria-targeted vitamin E) and their potential for the treatment of cardiovascular disease.