The Open Nursing Journal




ISSN: 1874-4346 ― Volume 13, 2019
RESEARCH ARTICLE

Non-adherence to Immunosuppressant after Lung Transplantation – A Common Risk Behavior



Lennerling Annette1, 2, *, Kisch Annika3, 4, Forsberg Anna4, 5
1 Institute of Health and Care Sciences, University of Gothenburg, Gothenburg, Sweden
2 The Transplant Centre, Sahlgrenska University Hospital, Gothenburg, Sweden
3 Department of Haematology at Skåne University Hospital, Lund, Sweden
4 Institute of Health Sciences at Lund University, Lund, Sweden
5 Department of Thoracic Transplantation and Cardiology, Skåne University Hospital, Lund, Sweden

Abstract

Background:

After lung transplantation, life-long treatment with immunosuppressive medication is required to prevent rejection and graft loss but adherence to immunosuppressive treatment may be difficult for the lung recipient. Adherence is essential and non-adherence to immunosuppressive treatment can lead to graft loss and death.

Objective:

The aim of this cross-sectional study was to investigate the prevalence of non-adherence 1 to 5 years after lung transplantation in relation to symptom burden, health literacy, psychological well-being and relevant demographic variables.

Methods:

117 adult lung recipients, due for their annual follow-up 1-5 years after lung transplantation, participated. Four self-report instruments were used for assessment: the Basel Assessment of Adherence with Immunosuppressive Medication Scale, the Newest Vital Sign, the Psychological General Well-Being and the Organ Transplant Symptom and Wellbeing Instrument. Statistical analysis was performed.

Results:

Thirty percent of the lung recipients were non-adherent. The most common non-adherence dimension was not taking a dose (43%) and not being punctual with the regimen (80%). Of those working full time or part time, 43% were non-adherent (p=.032). A higher level of non-adherence was reported a long time after LuTx with the highest level at the 3-year follow-up.

Conclusion:

The level of non-adherence among lung recipients was high. The highest levels were found among those who had returned to work. Non-adherence increased with time after lung transplantation.

Keywords: Lung transplantation, Non-adherence, Symptoms, Health literacy, Well-being, Self-report instruments.


Article Information


Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 108
Last Page: 115
Publisher Id: TONURSJ-13-108
DOI: 10.2174/1874434601913010108

Article History:

Received Date: 20/12/2018
Revision Received Date: 27/02/2019
Acceptance Date: 27/03/2019
Electronic publication date: 30/04/2019
Collection year: 2019

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© 2019 Annette et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Transplant Centre Bruna straket 5, level 6, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden;Tel: +46704149918; E-mail: annette.lennerling@gu.se




1. INTRODUCTION

For patients with terminal vital organ failure such as heart, lungs, liver or kidneys, solid organ transplantation is a well-established treatment. A person’s immune defense system reacts to all cells that are unfamiliar to that specific individual which includes transplanted organs. Therefore, organ transplantation requires life-long treatment with immunosuppressive medication to prevent graft rejection, graft loss and death. Adherence to treatment is challenging for all patients with life-long treatment and it is well known that adherence to immunosuppressive treatment may be difficult for organ transplant recipients. However, adherence is essential as non-adherence to immunosuppressive treatment can lead to severe consequences for transplanted persons. Late acute graft rejection and graft loss are associated with non-adherence to immunosuppressive drugs as well as the development of so-called donor-specific antibodies [1De Geest S, Abraham I, Moons P, et al. Late acute rejection and subclinical noncompliance with cyclosporine therapy in heart transplant recipients. J Heart Lung Transplant 1998; 17(9): 854-63.[PMID: 9773856] -5Doyle IC, Maldonado AQ, Heldenbrand S, Tichy EM, Trofe-Clark J. Nonadherence to therapy after adult solid organ transplantation: A focus on risks and mitigation strategies. Am J Health Syst Pharm 2016; 73(12): 909-20.[http://dx.doi.org/10.2146/ajhp150650] [PMID: 27189855] ]. If a person develops donor-specific antibodies, the risk of graft rejection increases and it also makes it more difficult to find a suitable donor if re-transplantation is necessary [3Rodrigo E, Segundo DS, Fernández-Fresnedo G, et al. Within-patient variability in tacrolimus blood levels predicts kidney graft loss and donor-specific antibody development. Transplantation 2016; 100(11): 2479-85.[http://dx.doi.org/10.1097/TP.0000000000001040] [PMID: 26703349] , 4Pizzo HP, Ettenger RB, Gjertson DW, et al. Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence. Pediatr Nephrol 2016; 31(12): 2345-52.[http://dx.doi.org/10.1007/s00467-016-3422-5] [PMID: 27286686] ]. Studies on transplant recipients from North America show a higher level of non-adherence than studies from Europe [6Dew MA, DiMartini AF, De Vito Dabbs A, et al. Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation 2007; 83(7): 858-73.[http://dx.doi.org/10.1097/01.tp.0000258599.65257.a6] [PMID: 1746 0556] ]. Adherence can be defined as “the extent to which a person’s behaviour (taking medications, following a recommended diet and/or executing life-style changes) corresponds with the agreed recommendations from a health care provider. Explanations for non-adherence to all forms of long-term treatment are complex and multifactorial. It involves patient and treatment regimen factors, as well as factors related to the health care system/ healthcare team and socio-economic factors. Patient related factors can be forgetfulness, complicated medication regimen or experiences of side-effects. Heath care system factors can be the kind of information given, continuity of care and frequency of follow-up visits. Socio-economic factors can be the patients’ financial situation, poor social support, dysfunctional family situation or drug abuse [7WHO Adherence to Long-Term Therapies- Evidence for Action. 2003.http://www.who.int/chp/knowledge/publications/adherence_full_report.pdf]. It is common for patients on immunosuppressive therapy to experience high symptom levels related to the treatment, e.g. trembling hands, diarrhoea, changed body image or pain, with women being affected to a higher degree [8Lennerling A, Forsberg A. Self-reported non-adherence and beliefs about medication in a Swedish kidney transplant population. Open Nurs J 2012; 6: 41-6.[http://dx.doi.org/10.2174/1874434601206010041] [PMID: 22509233] , 9Lundmark M, Lennerling A, Almgren M, Forsberg A. Recovery, symptoms, and well-being one to five years after lung transplantation - A multi-centre study. Scand J Caring Sci 2018. Epub ahead of print[http://dx.doi.org/10.1111/scs.12618] [PMID: 30320482] ]. This can result in decreased quality of life and may affect the level of adherence to treatment [10Kugler C, Fischer S, Gottlieb J, et al. Symptom experience after lung transplantation: impact on quality of life and adherence. Clin Transplant 2007; 21(5): 590-6.[http://dx.doi.org/10.1111/j.1399-0012.2007.00693.x] [PMID: 1784 5632] , 11Kugler C, Geyer S, Gottlieb J, Simon A, Haverich A, Dracup K. Symptom experience after solid organ transplantation. J Psychosom Res 2009; 66(2): 101-10.[http://dx.doi.org/10.1016/j.jpsychores.2008.07.017] [PMID: 1915 4852] ]. A meta-analysis revealed that patients suffering from depression have a three times greater risk of non-adherence to medical treatment than patients without depression [12DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med 2000; 160(14): 2101-7.[http://dx.doi.org/10.1001/archinte.160.14.2101] [PMID: 10904452] ]. Furthermore, a person’s ability to obtain, process and understand basic health information in order to make informed decisions about health behaviour, i.e., health literacy [13Ratzan SC, Parker RM. Introduction.National Library of Medicine Current Bibliographies in Medicine: Health Literacy 2000.] affects transplant outcomes [14Miller-Matero LR, Bryce K, Hyde-Nolan ME, Dykhuis KE, Eshelman A, Abouljoud M. Health literacy status affects outcomes for patients referred for transplant. Psychosomatics 2016; 57(5): 522-8.[http://dx.doi.org/10.1016/j.psym.2016.04.001] [PMID: 27231187] ].

Non-adherence to immunosuppressive treatment is complex, difficult to measure and there is no gold standard available, although self-reporting is generally considered to be an essential part of adherence assessment [15Dobbels F, Berben L, De Geest S, et al. The psychometric properties and practicability of self-report instruments to identify medication nonadherence in adult transplant patients: A systematic review. Transplantation 2010; 90(2): 205-19.[http://dx.doi.org/10.1097/TP.0b013e3181e346cd] [PMID: 20531073] ]. A recent systematic review including 30 relevant studies revealed that non-adherence to immunosuppressive medication after lung transplantation ranged from 2.3% to 72.2% [16Hu L, Lingler JH, Sereika SM, et al. Nonadherence to the medical regimen after lung transplantation: A systematic review. Heart Lung 2017; 46(3): 178-86.[http://dx.doi.org/10.1016/j.hrtlng.2017.01.006] [PMID: 28187909] ]. None of the reviewed studies were conducted in a Scandinavian context. This study stems from the assumption that the factors identified in previous literature of importance for non-adherence are relevant also for Swedish lung recipients. Thus the aim of this study was to investigate the prevalence of non-adherence 1-5 years after lung transplantation in relation to relevant sociodemographic variables, health literacy, symptom burden and psychological well-being and in a Swedish context.

2. MATERIALS AND METHODS

This multicentre cross-sectional cohort study is a part of the Swedish national study entitled Self-Management After Thoracic Transplantation (SMATT). The inclusion criteria were; adult (>18 yrs) lung recipients due for an annual follow-up 1-5 years after lung transplantation (LuTx) at either of the two thoracic transplant centres in Sweden (Lund & Gothenburg), Swedish speaking, mentally lucid, not hospitalized and without on-going rejection treatment with high dose steroids. The study was performed between 2014 and 2015, at that time 204 lung recipients were due for the yearly follow-up, of whom 117 (57%) fulfilled the inclusion criteria, agreed to participate and were included in the study. The reasons for non-participation in the study were; poor health status, language barriers, declining to participate for unknown reasons and staff shortages that resulted in lack of time to assess persons for inclusion in the study.

The Regional Ethical Review Board in Lund, Sweden granted permission to perform this study (D-nr 2014-124). All participants gave their written informed consent. The information provided by the participants was kept confidential and stored by the researchers in accordance with the Swedish personal data act; PuL-[1998:204].

2.1. The Instruments and Data Collection

Data collection was done when the study participants were attending their routine 1-5 years follow-up after LuTx. Four instruments were used in this study, two interview questionnaires, the Basel Assessment of Adherence with Immunosuppressive Medication Scale (BAASIS®) [17Schäfer-Keller P, Steiger J, Bock A, Denhaerynck K, De Geest S. Diagnostic accuracy of measurement methods to assess non-adherence to immunosuppressive drugs in kidney transplant recipients. Am J Transplant 2008; 8(3): 616-26.[http://dx.doi.org/10.1111/j.1600-6143.2007.02127.x] [PMID: 1829 4158] ] and the Newest Vital Sign (NVS) [18Marsicano EdeO, Fernandes NdaS, Colugnati F, et al. Transcultural adaptation and initial validation of Brazilian-Portuguese version of the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS) in kidney transplants. BMC Nephrol 2013; 14: 108. [PubMed].[http://dx.doi.org/10.1186/1471-2369-14-108] [PMID: 23692889] ] and two questionnaires for completion by the participants, the Psychological General Well-Being (PGWB) [19Weiss BD, Mays MZ, Martz W, et al. Quick assessment of literacy in primary care: the newest vital sign. Ann Fam Med 2005; 3(6): 514-22.[http://dx.doi.org/10.1370/afm.405] [PMID: 16338915] , 20Wiklund I, Karlberg J. Evaluation of quality of life in clinical trials. Selecting quality-of-life measures. Control Clin Trials 1991; 12(4)(Suppl.): 204S-16S.[http://dx.doi.org/10.1016/S0197-2456(05)80024-8] [PMID: 1663856] ] and the Organ Transplant Symptom and Wellbeing Instrument (OTSWI) [21Dimenäs E, Carlsson G, Glise H, Israelsson B, Wiklund I. Relevance of norm values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease. Scand J Gastroenterol Suppl 1996; 221: 8-13.[http://dx.doi.org/10.3109/00365529609095544] [PMID: 9110389] ].

The BAASIS®, a self-report instrument (the interview version) [17Schäfer-Keller P, Steiger J, Bock A, Denhaerynck K, De Geest S. Diagnostic accuracy of measurement methods to assess non-adherence to immunosuppressive drugs in kidney transplant recipients. Am J Transplant 2008; 8(3): 616-26.[http://dx.doi.org/10.1111/j.1600-6143.2007.02127.x] [PMID: 1829 4158] ], was used for assessing adherence to immunosuppressive drugs. The BAASIS® is operationalised to measure four dimensions of adherence during the previous four weeks; taking (taking the prescribed immunosuppressive), timing (taking immunosuppressive every 12 hrs, +/- 2 hrs), drug holidays (skipping immunosuppressive > 24 hrs) and dose changing (changing from the prescribed dose). If the respondent reports non-adherence to any of the four dimensions, she/he is considered non-adherent [17Schäfer-Keller P, Steiger J, Bock A, Denhaerynck K, De Geest S. Diagnostic accuracy of measurement methods to assess non-adherence to immunosuppressive drugs in kidney transplant recipients. Am J Transplant 2008; 8(3): 616-26.[http://dx.doi.org/10.1111/j.1600-6143.2007.02127.x] [PMID: 1829 4158] ]. The BAASIS has not been validated in the Swedish language but has been used in other transplant populations (Cronbach α = 0.7) [18Marsicano EdeO, Fernandes NdaS, Colugnati F, et al. Transcultural adaptation and initial validation of Brazilian-Portuguese version of the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS) in kidney transplants. BMC Nephrol 2013; 14: 108. [PubMed].[http://dx.doi.org/10.1186/1471-2369-14-108] [PMID: 23692889] ].

The health literacy level was assessed using the NVS operationalised to assess both numeric and word literacy. It has been shown to have good internal consistency (Cronbach α = 0.76) [19Weiss BD, Mays MZ, Martz W, et al. Quick assessment of literacy in primary care: the newest vital sign. Ann Fam Med 2005; 3(6): 514-22.[http://dx.doi.org/10.1370/afm.405] [PMID: 16338915] ]. The NVS has six short interview questions. Study participants were provided with a nutrition label and asked six questions to assess their health literacy level. The responses were recorded on a special score sheet, which also contained the correct answers. The health literacy level is based on the number of correct responses, where a score of 0-1 indicates low health literacy; 2-3 possibly limited health literacy and 4-6 adequate HL.

The interviews, i.e. BAASIS and NVS, were performed by either one of the two transplant nurses working at the two transplant outpatient-clinics. These four nurses were trained in how to use the instruments prior to the study. The questions were posed to the LuTx recipients at their 1-5 year follow-up visit at the transplant outpatient-clinic by the transplant nurse in a non-threatening, non-judgmental way.

The Swedish version of the PGWB instrument was used to measure psychological well-being and distress [20Wiklund I, Karlberg J. Evaluation of quality of life in clinical trials. Selecting quality-of-life measures. Control Clin Trials 1991; 12(4)(Suppl.): 204S-16S.[http://dx.doi.org/10.1016/S0197-2456(05)80024-8] [PMID: 1663856] , 21Dimenäs E, Carlsson G, Glise H, Israelsson B, Wiklund I. Relevance of norm values as part of the documentation of quality of life instruments for use in upper gastrointestinal disease. Scand J Gastroenterol Suppl 1996; 221: 8-13.[http://dx.doi.org/10.3109/00365529609095544] [PMID: 9110389] ]. The instrument contains 22 items, which is operationalised into six dimensions: anxiety, depressed mood, positive well-being, self-control, general health and vitality. Inter-item correlation values range from 0.53-0.79 and Cronbach’s Alpha ranges from 0.61-0.89. For each of the 22 questions, response was given on a six-point Likert-scale with different response alternatives for every question. The PGWB total sum-score was 132, while higher scores indicate better psychological well-being. A normal sum-score is in the range of 100-105. The sum score was dichotomized as a cut off between low (0-100) and good physiological well-being (101- 132).

The OTSWI was developed to measure symptom prevalence, symptom distress and transplant specific well-being after organ transplantation [22Forsberg A, Persson LO, Nilsson M, Lennerling A. The organ transplant symptom and well-being instrument - psychometric evaluation. Open Nurs J 2012; 6: 30-40.[http://dx.doi.org/10.2174/1874434601206010030] [PMID: 22523527] ]. It was used to assess transplant specific symptoms and well-being. It measures distress from eight dimensions and 20 transplant specific symptoms. The distress is assessed on a five-point Likert-scale: “not at all” (0), “a little” (1), “somewhat” (2), “quite a bit” (3), and “very much” (4). The OTSWI has a sum score of 0-80, where lower scores indicate higher well-being. Item scale correlations ranged from 0.66 -0.98 and the Cronbach’s alpha coefficient was satisfactory for all scales, ranging from 0.81-0.92.

The PGWB and OTSWI instruments are self-reported questionnaires, which were filled in by the participants and returned at the routine follow-up appointment. At this time point, they also filled in an author constructed questionnaire with demographic variables regarding age, sex, social situation, educational level and ability to work.

2.2. Data Analysis

The SPSS Statistics (SPSS Inc., IBM Corporation, Armonk, NY, USA) was used for analysing data, which were mostly ordinal. Ordered category data are presented with medians and percentiles (P25, P75). Values of P < 0.05 (two-tailed) were considered statistically significant. Age was dichotomised into two groups, younger and older than 50 years. The analysis was performed step-wise as follows exploring proportions one to five years after LuTx followed by proportional differences between unpaired groups which were analysed with Chi-Square test. Differences in health literacy, symptom burden and psychological well-being between adherent and non-adherent recipients were explored with Mann Witney U test. Finally, differences between three unpaired groups, i.e. educational level, were analysed with Kruskal Wallis test.

3. RESULTS

117 participants were due for their annual follow-up as follows; 1 year (n=35), 2 years (n=28), 3 years (n=23), 4 years (n=20) and 5 years (n=11). The demographics of the study participants are presented in Table 1 and indications for LuTx are presented in Table 2, where the two most prevalent indications for transplantation were chronic obstructive pulmonary disease and lung fibrosis. The median age was 56.5 years and the mean age was 53.5 years (SD=12.5 years), ranging from 18-74 years. Sex was equally distributed (59 women and 58 men) and 64% of the participants were married.

Table 1
Demographic characteristics at follow-up 1-5 years after lung transplantation.


The BAASIS showed that 30% of the lung recipients were non-adherent (35/117). The non-adherence regarding taking was 43% (15/35) and the most frequent non-adherence behaviour was timing (punctuality), 80% (28/35). Ten participants reported more than one non-adherence dimension (29%), where the most common combination was taking and timing.

Of those working full or part-time 43% were non-adherent. Lung recipients able to work full or part-time were significantly (p=0.032) less adherent than those unable to work (Table 3).

No differences in adherence were found when comparing two or more independent groups, i.e., sex, patients older or younger than 50 years, marital status, educational level and ability to work.

The prevalence of non-adherence differed significantly between the follow-up years (p=0.047). Non-adherence was 14% at 1 year follow-up and 52% at the 3 year follow-up. It was approximately 30% at the 2, 4 and 5 year follow-ups (Table 4).

Health literacy was similar in the adherent and non-adherent group (p=0.628). Eight percent in the adherent group and 3% in the non-adherent group scored 0-1 on the NVS indicating low health literacy, while 14% in the adherent group and 17% in the non-adherent group scored 2-3 indicating possibly limited health literacy. A total of 78% in the adherent group and 80% in the non-adherent group scored 4-6, suggesting an adequate health literacy level in both the adherent and the non-adherent groups.

The OTSWI sum score ranged from 0-57 with a mean of 16.8 (SD 12.37) and 30% of the study group scored under 10, indicating a high level of well-being. The symptom burden was greater in the non-adherent group regarding low appetite (p=0.012) and diarrhoea (p=0.007).

The PGWB sum score was dichotomized to low or good psychological well-being where 44% of the adherent group and 40% of the non-adherent group rated low psychological general well-being, which difference was not significant (p=0.779). No relationships were found between adherence and overall psychological well-being, age or health literacy.

Table 2
Indications for transplantation, type of lung transplant and immunosuppressive medications, reported by the study participants (n= 117).


Table 3
Factors related to non-adherence to immunosuppressive medication.


Table 4
This table shows the distribution of adherence and non-adherence among 117 lung recipients with regard to the year of follow-up.


4. DISCUSSION

The key finding of this study was that the level of non-adherence among lung recipients was high. The highest levels were found among those who had returned to work. A higher level of non-adherence was reported a long time after LuTx with the highest level at the 3 year follow-up.

When screening with the BAASIS, the level of non-adherence among the lung recipients was surprisingly high at 30%, which is worrying. A high level of non-adherence (27%) measured with the BAASIS after LuTx was also shown by Drick et al. [23Drick N, Seeliger B, Fuge J, et al. Self-reported non-adherence to immunosuppressive medication in adult lung transplant recipients-A single-center cross-sectional study. Clin Transplant 2018; 32(4): e13214.[http://dx.doi.org/10.1111/ctr.13214] [PMID: 29380445] ]. In contrast, Bosma and colleagues found that only 8% of the lung recipients were non-adherent, although in that study the instrument BAASIS was not used to measure non-adherence i.e. other instrument of measuring adherence was used, which makes it difficult to compare studies [24Bosma OH, Vermeulen KM, Verschuuren EA, Erasmus ME, van der Bij W. Adherence to immunosuppression in adult lung transplant recipients: prevalence and risk factors. J Heart Lung Transplant 2011; 30(11): 1275-80.[http://dx.doi.org/10.1016/j.healun.2011.05.007] [PMID: 21724418] ].

An established goal after organ transplantation is that the recipient returns to work within 24 months [25Cavallini J, Forsberg A, Lennerling A. Social function after solid organ transplantation: An integrative review. Nord J Nurs Res 2015; 35(4): 227-34.[http://dx.doi.org/10.1177/0107408315592335] , 26Forsberg A, Cavallini J, Fridh I, Lennerling A. The core of social function after solid organ transplantation. Scand J Caring Sci 2016; 30(3): 458-65.[http://dx.doi.org/10.1111/scs.12264] [PMID: 26395270] ]. An important finding in the present study was the difference in adherence among the persons who had returned to work compared to those who were not working, where the persons working had a significantly higher level of non-adherence. Of those working full or part-time, 43% were non-adherent. Based on our clinical experience, if you are busy with your normal everyday life and feel healthy, it is easy to forget that you have a condition that requires continuous medication. This indicates that persons in full or part-time employment need more self-management support from the health care team to develop medication routines suitable for their everyday life. We suggest that the most appropriate approach is person-centred care with an individual assessment of adherence, work situation and social situation on a regular basis.

Non-adherence increased with time since transplantation and was 14% at the 1 year follow-up, peaking to 52% at the 3 year follow-up and remained at 30% at the 5 year follow-up.

That non-adherence increases over time after transplantation has also been shown by others [23Drick N, Seeliger B, Fuge J, et al. Self-reported non-adherence to immunosuppressive medication in adult lung transplant recipients-A single-center cross-sectional study. Clin Transplant 2018; 32(4): e13214.[http://dx.doi.org/10.1111/ctr.13214] [PMID: 29380445] , 27De Geest S, Burkhalter H, Bogert L, Berben L, Glass TR, Denhaerynck K. Describing the evolution of medication nonadherence from pretransplant until 3 years post-transplant and determining pretransplant medication nonadherence as risk factor for post-transplant nonadherence to immunosuppressives: The Swiss Transplant Cohort Study. Transpl Int 2014; 27(7): 657-66.[http://dx.doi.org/10.1111/tri.12312] [PMID: 24628915] ]. An explanation can be that over time when you experience well-being it may be difficult to comprehend that the medication is still needed. These results indicate that regular screening of adherence and long-term follow-up after LuTx are of great importance. Therefore, individualized follow-up after LuTx is needed. A suggestion to achieve this is digitalized follow-up in the form of frequent reminders about medication intake as a complement to face to face follow-up visits.

There is also a need to transform the follow-up after LuTx from the medical to the health promotion perspective through self-management support [28Bossy D, Ruud Knutsen I, Rogers A, Foss C. Moving between ideologies in self-management support- A qualitative study. Health Expect 2018 Oct 9; Epub ahead of print[http://dx.doi.org/10.1111/hex.12833] [PMID: 30289189] ]. The medical perspective presupposes a form of practice that aligns with expectations that patients follow and comply with medical directions in a manner that acknowledges professional power and legitimacy [29Martinussen PE, Magnussen J. Resisting market-inspired reform in healthcare: the role of professional subcultures in medicine. Soc Sci Med 2011; 73(2): 193-200.[http://dx.doi.org/10.1016/j.socscimed.2011.04.025] [PMID: 2168 9875] , 30Reay T, Hinings CR. Managing the rivalry of competing institutional logics. Organ Stud 2009; 30: 629-52.[http://dx.doi.org/10.1177/0170840609104803] ]. The medical perspective involves a modus operandi that emphasizes treatment guided by an expert and depicts patients as needing help and health professionals as legitimate experts in ensuring that this help is provided [31Knutsen IR, Foss C. Caught between conduct and free choice-a field study of an empowering programme in lifestyle change for obese patients. Scand J Caring Sci 2011; 25(1): 126-33.[http://dx.doi.org/10.1111/j.1471-6712.2010.00801.x] [PMID: 2051 8867] ]. In contrast, health promotion involves both person-oriented and group-oriented dimensions [32Ashcroft R. Health promotion and primary health care: Examining the discourse. Soc Work Public Health 2015; 30(2): 107-16.[http://dx.doi.org/10.1080/19371918.2014.938395] [PMID: 25375065] ], suggesting that in health promotion the person is seen as part of her/his social context. Health promotion is aimed at empowering individuals to take control of their health, which is depicted as a process of enabling persons to take increased responsibility for their own health and well-being [28Bossy D, Ruud Knutsen I, Rogers A, Foss C. Moving between ideologies in self-management support- A qualitative study. Health Expect 2018 Oct 9; Epub ahead of print[http://dx.doi.org/10.1111/hex.12833] [PMID: 30289189] ]. Thus, providing health promotion to lung recipients means helping them by addressing the non-medical factors of their health, i.e., acknowledging patients’ knowledge of their own health. Transplant professionals must change their way of thinking and frames of reference when meeting lung recipients and focus on well-being and health rather than symptoms and limitations [9Lundmark M, Lennerling A, Almgren M, Forsberg A. Recovery, symptoms, and well-being one to five years after lung transplantation - A multi-centre study. Scand J Caring Sci 2018. Epub ahead of print[http://dx.doi.org/10.1111/scs.12618] [PMID: 30320482] ]. The LuTx recipient is the expert on her/his everyday life and can thus provide suggestions and interventions that will most likely facilitate adherence.

Previously, there have been numerous explanations behind non-adherence to long-term therapy such as the Health Belief Model [33Becker MH, Maiman LA. Sociobehavioral determinants of compliance with health and medical care recommendations. Med Care 1975; 13(1): 10-24.[http://dx.doi.org/10.1097/00005650-197501000-00002] [PMID: 1089 182] ], the Theory of Planned Behavior [34Fishbein M, Ajzen I. Belief, Attitude, Intention and Behavior 1975.], the Social Learning Theory [35Bandura A. Social cognitive theory of moral thoughts and action.Handbook of Moral Behavior and Development 1991; Vol. 1: 45-103.] and the Necessity-Concerns Framework [36Horne R, Chapman SCE, Parham R, Freemantle N, Forbes A, Cooper V. Understanding patients’ adherence-related beliefs about medicines prescribed for long-term conditions: A meta-analytic review of the Necessity-Concerns Framework. PLoS One 2013; 8(12): e80633.[http://dx.doi.org/10.1371/journal.pone.0080633] [PMID: 24312488] ]. These models suggest that non-adherence is largely intentional, indicating that patients after assessing pros and cons make a rational choice not to adhere. However, it has also been suggested that non-adherence could be unintentional [37Lehane E, McCarthy G. Intentional and unintentional medication non-adherence: a comprehensive framework for clinical research and practice? A discussion paper. Int J Nurs Stud 2007; 44(8): 1468-77.[http://dx.doi.org/10.1016/j.ijnurstu.2006.07.010] [PMID: 16973166] ]. Unintentional non-adherence does not depend on the choice of the patient but rather on factors such as poor understanding of the prescription, difficulty to access the prescribed medication, intervention of the patient’s habits, lack of memory, defence mechanisms or simply irrationality [38Reach G. The mental mechanisms of patient adherence to long-term therapies, mind and care, forward by Pascal Engel, philosophy and medicine 2015; 207.]. Our understanding is that the high level of non-adherence in our study stems from mainly unintentional behaviour due to complicated logistics in everyday life.

Reach et al. [39Reach G, Boubaya M, Brami Y, Lévy V. Disruption in time projection and non-adherence to long-term therapies. Patient Prefer Adherence 2018; 12: 2363-75.[http://dx.doi.org/10.2147/PPA.S180280] [PMID: 30519002] ] tested the hypothesis that adherence to medication in chronic diseases, e.g. diabetes is linked to time projection. This is defined as consisting of three psychological constructs; a) patience/impatience, b) greater or lesser ability to imagine remote future events (size of temporal horizon) and c) perception of the degree of physical similarity of current self to future self. They suggest that disruption in the time projection plays a role in both intentional and unintentional non-adherence [39Reach G, Boubaya M, Brami Y, Lévy V. Disruption in time projection and non-adherence to long-term therapies. Patient Prefer Adherence 2018; 12: 2363-75.[http://dx.doi.org/10.2147/PPA.S180280] [PMID: 30519002] ]. Thus, some LuTx recipients with disruption in time projection may prefer either as a personal choice, or under pressure of external elements, such as social adaptation or demands of going back to work to prioritise immediate rewards i.e. making a choice not to adhere. The study by Reach et al. [39Reach G, Boubaya M, Brami Y, Lévy V. Disruption in time projection and non-adherence to long-term therapies. Patient Prefer Adherence 2018; 12: 2363-75.[http://dx.doi.org/10.2147/PPA.S180280] [PMID: 30519002] ], onpatients with diabetes reported that there was a unique association between adherence to medication and patients’ time projection. The ability to imagine oneself physically in the future was linked to adherence. Transferred to lung recipients, the persons who have the ability to view themselves as long-term survivors might be better off, while impatient persons need more short-term rewards for adherence to be motivated instead of advised on how to avoid long-term complications from their LuTx. This is an interesting hypothesis that needs further exploration.

To increase adherence to immunosuppressant drugs after LuTx we suggest the following:

  • Special focus on those who have returned to work, which is an important part of their social context.
  • Individualized and tailored self-management support based on the social situation and workload.
  • Provide digital tools suitable for each person’s needs.
  • If necessary, establish a firm nurse-patient relationship based on a partnership and a contract regarding acceptable adherence behaviour.
  • Increase the accessibility of care by means of e-health or mobile-health solutions, which should be considered an option when transplanted persons live far away from the out-patient clinic as well as for persons in full or part-time employment who may have limited time for hospital visits.
  • All this requires staff continuity in order to establish trustful caring relationships in the outpatient clinics focusing on health promotion.

Limitations of this study are the cross-sectional design i.e. it is only a snapshot at a certain time-point and the study participants were not followed over time. There is also the risk of recall bias when using instruments asking for data during a time period. Health literacy was measured with the instrument NVS, which is not specifically developed for the transplant recipients. Splitting the study population in years of follow-up makes each group small in numbers.

CONCLUSION

In conclusion, this study shows that non-adherence to immunosuppressant among lung recipients was high, with the highest non-adherence levels among those who had returned to work. The most frequent non-adherence behaviours were taking and timing, which are usually associated with forgetfulness and routines. A higher level of non-adherence was also reported after a longer period of time after LuTx.

LIST OF ABBREVIATIONS

LuTx = Lung Transplantation
BAASIS = The Basel Assessment of Adherence with Immunosuppressive Medication Scale
NVS = The Newest Vital Sign
PGWB = Psychological General Well-Being
OTSWI = The Organ Transplant Symptom and Wellbeing Instrument

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

The Regional Ethical Review Board in Lund, Sweden granted permission to perform this study (D-nr 2014-124).

HUMAN AND ANIMAL RIGHTS

No animals were used in this research. All human research procedures followed were in accordance with the ethical standards of the committee responsible for human experimentation (institutional and national), and with the Helsinki Declaration of 1975, as revised in 2013.

CONSENT FOR PUBLICATION

All participants gave their written informed consent.

AVAILABILITY OF DATA AND MATERIALS

There is no webpage from where the data can be retrieved. However, calculations and raw data can be retrieved upon request.

FUNDING

This work was financially supported by the Thure Carlsson Foundation.

CONFLICT OF INTEREST

The authors declare no conflict of interest, financial or otherwise.

ACKNOWLEDGEMENTS

We gratefully acknowledge Ulrika Nibble, Elisabeth Svebring, Marie Stiernspetz and Kristine Kappelin who facilitated the recruitment of participants and data collection at the Out-patient Clinics at the Department of Thoracic Transplantation and Cardiology, Skåne University Hospital in Lund and The Transplant Centre, Sahlgrenska University Hospital in Gothenburg (both in Sweden).

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