Healthy Adult LDL-C Bears Reverse Association with Serum IL-17A Levels
Azam Roohi1, *, Mina Tabrizi2, Mehdi Yaseri3, Fereshteh Mir Mohammadrezaei4, Behrouz Nikbin5
1 Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
2 Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3 Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4 Department of Biology, Faculty of Science, University of Mazandaran, Mazandaran, Babolsar, Iran
5 Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Hypercholesterolemia is a modifiable risk factor in atherosclerosis with a complex association with inflammation.
In the present study, the association between low-density lipoprotein cholesterol (LDL-C) and interleukin 17A (IL-17A), as an inflammatory cytokine, was investigated. In addition to IL-17A, serum levels of interleukin 23 (IL-23) and transforming growth factor β (TGF-β), as effective cytokines in T helper 17 cell (Th17) development, were also determined.
Cytokine levels were measured using enzyme-linked immunosorbent assay (ELISA) in healthy subjects with LDL-C<130 versus LDL-C=>130 mg/dL.
Although IL-17A is an inflammatory cytokine and a positive association between its levels and LDL-C is expected, the data obtained in this study provide support for a reverse association (p<0.05).
Inflammation plays a major role in atherosclerosis development; however, various inflammatory components involved in atherosclerosis assert their own unique association with hypercholesterolemia.
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* Address correspondence to this author at the Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, 14716-13151, Iran, Tel: +98-21-42933149, Fax: +98-21-88954913; Email: email@example.com