The Open Bioactive Compounds Journal




ISSN: 1874-8473 ― Volume 7, 2019

Sphingosine Kinase 2 Inhibitor Accelerates Fas-Mediated Cell Death Progression in A20/2J Cells



Miki Hara-Yokoyama*, 1, Kazue Terasawa1, Akio Kihara2, Jin-Wook Kim2, 3, Chan-Seo Park2, 4, Yoshio Hirabayashi5, Yasuyuki Igarashi2 , Masaki Yanagishita1
1 Department of Hard Tissue Engineering, Biochemistry, Division of Bio-Matrix, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan,
2 Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12-jo, Nishi 6-choume, Kita-ku, Sapporo 060-0812, Japan,
3 LCS biotech, 3-26, Pil-dong, Chung-gu, Seoul 100-715, Korea, (Present address)
4 Department of Chemical and Biochemical Engineering, Dongguk University, 3-26, Pil-dong, Chung-gu, Seoul 100-715, Korea (Present address)
5 Brain Science Institute, The Institute of Physical and Chemical Research (Riken), 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

Abstract

A sphingosine kinase (SPHK) type 2 inhibitor, SG-12, inhibited the SPHK2 activity in A20/2J cells and promoted Fas-dependent cell death. The effect of SG-12 on cell death was relieved by SPHK2 transfection but not by SPHK1 transfection. The results suggest a SPHK2-specific suppression of Fas-dependent cell death.

Key Words: Sphingosine-1-phosphate, Sphingosine kinase 2, Fas, Cell death, B cell.


Article Information


Identifiers and Pagination:

Year: 2008
Volume: 1
First Page: 22
Last Page: 27
Publisher Id: TOBCJ-1-22
DOI: 10.2174/1874847300801010022

Article History:

Received Date: 7/8/2008
Revision Received Date: 16/9/2008
Acceptance Date: 19/9/2008
Electronic publication date: 28/11/2008
Collection year: 2008

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© Ahlberg etal.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Department of Hard Tissue Engineering, Biochemistry, Division of Bio-Matrix, Graduate School Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan; Tel: +81 3 5803 5567; Fax: +81 3 5803 0187; E-mail: m.yokoyama.bch@tmd.ac.jp



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