The Open Bioactive Compounds Journal




ISSN: 1874-8473 ― Volume 7, 2019

Biotransformation of Khellin to Khellol by Aspergillus Niger and the Evaluation of their Biological Activities



Ahmed Ashour1, 2, Saleh El-Sharkawy2, 3, Mohamed Amer2, Fatma Abdel Bar2, Amira Mera1, 2, Toshiro Nagata1, Ryuichiro Kondo1, Kuniyoshi Shimizu1, *
1 Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581 Japan
2 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
3 Department of Pharmacognosy, Faculty of pharmacy, Delta University for Science and Technology, Egypt

Abstract

Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

Keywords: : Biotransformation. khellin, khellol, neuroprotective.


Article Information


Identifiers and Pagination:

Year: 2013
Volume: 4
First Page: 1
Last Page: 3
Publisher Id: TOBCJ-4-1
DOI: 10.2174/1874847320130628001

Article History:

Received Date: 15/5/2013
Revision Received Date: 23/5/2013
Acceptance Date: 4/6/2013
epreprint1/7/2013
Electronic publication date: 4/9/2013
Collection year: 2013

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© Ashour et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581 Japan; E-mail: shimizu@agr.kyushu-u.ac.jp



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Department of Pharmacy, World University of Bangladesh, Bangladesh


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