The Open Bioactive Compounds Journal


ISSN: 1874-8473 ― Volume 8, 2020

Antidiabetic and Antioxidant Potential of GancidinW from Streptomyces Paradoxus VITALK03

Lokesh Ravi, Adhithya Ragunathan, Kannabiran Krishnan*
School of Biosciences and Technology, VIT University, Vellore-632014, Tamil Nadu, India.



The aim of the present study was to analyse the antidiabetic and antioxidant potential of GancidinW (GW) extracted from Streptomyces paradoxus VITALK03.

Materials and Methods:

Antidiabetic potential of GW was evaluated by assay of α-amylase and α-glucosidase inhibitory activity; haemoglobin glycosylation and yeast glucose uptake. The antioxidant potential of GW was assessed by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation decolorization assay and superoxide assay. The inhibition of α-amylase and α-glucosidase by GW was also studied by in Silico molecular docking analysis.


GW (1mg/ml) showed 69.32% of α-amylase and 54.04% of α-glucosidase inhibitory activity. GW (1mg/ml) prevented haemoglobin glycosylation up to 30.92% and the glucose uptake by yeast cells was increased up to 64.38%. The binding interaction GW with α-amylase showed the least free binding energy of -6.09Kcal/mol and -7.53Kcal/mol with α-glucosidase by docking studies. GW also demonstrated moderate antioxidant activity in all the antioxidant assays performed.


The results of this study suggests that the antidiabetic and antioxidant potential of GW can be probed further to develop GW as effective antidiabetic agent.

Keywords: GancidinW, Antioxidant, Antidiabetic activity, α-amylase, α-glucosidase, Glycosylation.

Article Information

Identifiers and Pagination:

Year: 2017
Volume: 05
First Page: 31
Last Page: 42
Publisher Id: TOBCJ-5-31
DOI: 10.2174/1874847301705010031

Article History:

Received Date: 19/06/2017
Revision Received Date: 05/09/2017
Acceptance Date: 09/09/2017
Electronic publication date: 31/10/2017
Collection year: 2017

© 2017 Ravi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the School of Biosciences and Technology, VIT University, Vellore-632014, Tamil Nadu, India; Tel: 0416-2202024; E-mail:

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