Neurobiology Laboratory, Department of Zoology, University of Mysore, Manasagangotri, Mysuru- 570006, Karnataka, India
Natural antioxidants show neuroprotective potential to protect against neurodegenerative disorders in experimental animals. There is a need to characterize newer promising neuroprotective natural molecules.
In the present study, we have compared the neuroprotective activity of 4hydroxyisophthalic acid (DHA-I), a novel natural antioxidant from the roots of Decalepis hamiltonii, with the other natural neuroprotective antioxidants, ellagic acid, quercetin and nicotinamide, against paraquat (PQ) neurotoxicity in D. melanogaster.
Flies exposed to multiple (sub-lethal) dose of PQ showed movement disorder characteristic of Parkinson’s disease (PD). The four natural antioxidants showed ameliorative effects against PQ neurotoxicity in the sub-acute model as seen in survivability, locomotor activity as well as oxidative stress markers including reactive oxygen species (ROS), lipid peroxidation and the endogenous antioxidant defenses.
Our study shows that the antioxidant compounds exhibit varying degrees of protection against PQ-induced oxidative stress and neurotoxicity with DHA-I, quercetin, and nicotinamide being the most effective and ellagic acid, the least potent in Drosophila. Our results show that mitochondrial Mn-SOD is a critical target for PQ neurotoxicity and the neuroprotection by the antioxidants involves the attenuation of mitochondrial ROS production and oxidative damage.
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