Expression of Nuclear β-Catenin in Rectal Versus Colonic Cancers
Rolf Aamodt*, 1, Johan Bondi1, Solveig Norheim Andersen2, Geir Bukholm3 , Ida R.K. Bukholm1
1 Department of Surgery
2 Department of Pathology, Akershus University Hospital, 1478 Loerenskog, Norway,
3 EpiGen Institute, University of Oslo, Norway
Rectal cancers have more local relapses than colonic cancers. Since nuclear β-catenin plays an important role
for the proliferation capacity of cells, we wanted to evaluate whether there may be differences in the expression pattern of
nuclear β-catenin between rectal and colonic adenocarcinomas, explaining the observations made in clinical practice. Sec-
tions from 235 rectal adenocarcinomas treated surgically in the years 1992 - 2000 were immunohistochemically stained
for β-catenin. Nuclear immunopositivity was recorded. The results were compared to the results of a similar examination
performed earlier on 162 colonic cancers. We found a higher protein expression of nuclear β-catenin in rectal cancers than
in colonic cancers. No statistically significant correlation was observed between nuclear expression of β-catenin in rectal
cancers and cancer specific survival. Our findings indicate that rectal cancers and colonic cancers are biologically different. The results might partly explain the clinical difference observed between rectal cancers and colonic cancers.
Received Date: 5/12/2007 Revision Received Date: 7/12/2007 Acceptance Date: 28/1/2008 Electronic publication date: 18/3/2008 Collection year: 2008
Bentham Science Publishers Ltd.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License(http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
* Address correspondence to this author at the Department of Surgery, Akershus University Hospital, 1478 Loerenskog, Norway;