Assessment of Kidney Safety Parameters Among Hiv-Infected Patients Starting a Tenofovir-Containing Antiretroviral Therapy
Roberto Manfredi*, Leonardo Calza
Abstract
To better evaluate the renal safety profile of tenofovir, we performed a retrospective study of HIV-infected naïve patients starting a first antiretroviral therapy between July 2005 and July 2008, and followed-up for 24 months. On the whole, 324 patients were enrolled: 201 tenofovir-exposed patients were compared with 123 tenofovir-unexposed subjects. In both unadjusted and adjusted analysis, tenofovir-exposed subjects had a significantly greater decline in glomerular filtration rate (GFR), and a significantly higher incidence of proximal tubular dysfunction through 24 months. Reduced glomerular and tubular functions were significantly associated with older age, diabetes, hypertension, and concomitant therapy with a HIV protease inhibitor.
Keywords: HIV, tenofovir, nephrotoxicity, glomerular filtration rate, tubulopathy.
Article Information
Article History:
Received Date: 01/9/2010
Revision Received Date: 30/11/2010
Acceptance Date: 06/12/2010
Electronic publication date: 26/01/2011
Collection year: 2011
© Manfredi and Calza; Licensee Bentham Open
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (
http://creativecommons.org/licenses/by/2.5/), which
permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
* Address correspondence to this author at the Infectious Diseases, University of Bologna, S. Orsola Hospital, Via Massarenti 11, I-40138 Bologna, Italy; Tel: +39 051 6363355; Fax: +39 051 343500; E-mail:
roberto.manfredi@unibo.it
Open Peer Review Details |
Manuscript submitted on 01-9-2010 |
Original Manuscript |
Assessment of Kidney Safety Parameters Among Hiv-Infected Patients Starting a Tenofovir-Containing Antiretroviral Therapy |