Monitoring of Vascular Endothelial Growth Factor in POEMS Syndrome
J Minarik *, 1, V Scudla1, J Bacovsky1, T Pika1
, P Petrova2
1 Department of Internal Medicine III, University Hospital Olomouc, Czech Republic
2 Department of Clinical Biochemistry, University Hospital Olomouc, Czech Republic
Abstract
POEMS syndrome is a clinical unit with a very heterogenous clinical behavior. Its diagnostics as well as monitoring are not easy and depend on clinician´s experience. We present three case reports of patients with POEMS syndrome with different clinical manifestation and course of the disease. Our presentation demonstrates the benefit of the use of biochemical parameter VEGF (vascular endothelial growth factor). Retrospective analysis revealed that VEGF behaved accordingly with the state of the disease, i.e. it increased in active phase and decreased with remission of the disease. We suggest the use of VEGF not only for the diagnostics but also as a potential marker of therapeutic response and for monitoring of the course of POEMS syndrome.
Keywords: POEMS syndrome, disease monitoring, VEGF.
Article Information
Article History:
Received Date: 4/6/2010
Revision Received Date: 19/8/2010
Acceptance Date: 26/8/2010
Electronic publication date: 29/10/2010
Collection year: 2010
© Minarik et al.; Licensee Bentham Open.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License(
http: //creativecommons.org/licenses/bync/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to this author at the Department of Internal Medicine III, University Hospital Olomouc, I. P. Pavlova 6 775 20 Olomouc, Czech Republic; Tel: 420-585-3362; Fax: 420-585-2526;
E-mail: abretina@email.cz
Open Peer Review Details |
Manuscript submitted on 4-6-2010 |
Original Manuscript |
Monitoring of Vascular Endothelial Growth Factor in POEMS Syndrome |