LETTER TO THE EDITOR


COVID-19 Cytokine Storm Complications in Asthmatic Patients



Entezar Mehrabi Nasab1, Seyyed Shamsadin Athari2, *
1 Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran


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Creative Commons License
© 2020 Nasab & Athari.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; E-mail: SS.Athari@zums.ac.ir


Abstract

The pandemic of coronavirus disease 2019 has inflicted millions of people in the world and caused severe complications in immunocompromised individuals. Some evidences suggest that severe COVID-19 complications are associated with the cytokine storm syndrome, contributing to the high mortality rate of the disease. Asthma is a complicated disease of the respiratory system. COVID-19 symptoms can be worse in asthmatic patients than others. Corticosteroids with anti-inflammatory functions which are used in asthmatic patients may have adverse outcomes in coronavirus infection and are not recommended for the treatment of COVID-19. Furthermore, asthmatic patients (using inhalation corticosteroids) have a suppressed immune system in the lung, which increases their susceptibility to COVID-19 infection.

Keywords: COVID-19, Asthma, Cytokine, Storm, Patient, Pandemy.