1 Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada
2 Tata Institute of Social Sciences, School of Development Studies, Mumbai, India
Anemia accounts for 40% of maternal deaths in India. In order to address this problem, the Government of India implemented the largest programme with the greatest potential to reduce maternal mortality by free distribution of Iron-Folic Acid (IFA) supplementations especially during Antenatal Care (ANC) visits. But the major concern among the policymakers and researchers has been poor adherence to the supplement among pregnant women. However, we tend to think that given the severity of the problem, there is no investigation on the adherence issue. Hence, the aim of the paper is to understand whether IFA consumption by pregnant women in India is largely a distribution problem of IFA supplements through ANC.
The distribution of Iron-Folic Acid (IFA) supplementation is not working especially through Antenatal Care (ANC) attendance. The program implementers believe that it is because of lack of adherence to IFA supplements by pregnant women. It is important to investigate the problem before any policy changes are made without proper evidence.
The purpose of this study is to examine whether the problem of IFA consumption by pregnant women is due to the problem of public distribution of IFA supplements through ANC attendance.
This study had used the fourth round of District Level Household Survey data, which collects information on IFA supplements, their distribution and consumption. Bivariate and tri-variate analyses were used to understand the relationship between IFA distribution to pregnant women and their consumption patterns in 19 Indian states and two Union Territories (UTs) of pregnant women (88,487) and between the age of 15-49 years.
In almost all the states except Chhattisgarh, more than 75% of the pregnant women consumed 100 or more IFA supplements when they received 100 or more IFA supplements from providers. Similar is the case even among those women who received 100 or more IFA supplements through 1 or 2 ANC attendance except Arunachal Pradesh (60%), Meghalaya (67%), Pondicherry (57%) and Andaman and Nicobar (0%). The consumption of IFA supplements among pregnant women gets better than 75% if they receive 100 or more supplements only after attending three or more ANCs.
It seems that distribution is a problem in the consumption of IFA supplements by pregnant women in India. Full antenatal attendance by the women could be part of the problem but not supplying at least 100 IFA supplementations to even those who attend ANC due to stock-outs and ineffective management is a serious concern. Hence, Governments should distribute at least the recommended 100 IFA supplements to the women in their 1st ANC attendance to address anaemia.
Keywords: Pregnant women, IFA supplement, ANC, Distribution and consumption, DLHS, India.
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* Address correspondence to this author at the Tata Institute of Social Sciences, School of Development Studies, V.N. Purav Marg, Eden Gardens, Deonar, Mumbai, Maharashtra 400088, India,
Is Distribution a Problem in Iron-Folic Acid Consumption in India? An Exploration of District Level Household Survey
Anaemia affects one-quarter of the world's population, but it is largely concentrated in the African continent. For instance, the Lancet study on global trends in the prevalence of anaemia in children and women reveals that though there has been some reduction in anaemia prevalence from the mid-1990s in some regions of the World, in case of central and west Africa much effort is needed to improve the health of women and children so that global targets can be achieved [1Stevens GA, Finucane MM, De-Regil LM, et al. Nutrition Impact Model Study Group (Anaemia). Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: A systematic analysis of population-representative data. Lancet Glob Health 2013; 1(1): e16-25.https://www.sciencedirect. com/science/article/pii/S2214109X13700019. [http://dx.doi.org/10.1016/S2214-109X(13)70001-9] [PMID: 25103581] ]. Globally, nearly 41.8% of pregnant women are anaemic [2McLean E, Egli I, Cogswell M, Benoist BD, Wojdyla D. Worldwide prevalence of anemia in preschool aged children, pregnant women and non-pregnant women of reproductive age. Nutritional anemia 2007; 1-12.https://www.research-collection.ethz.ch/ handle/ 18.104.22.16850/6024]. At least half of the burden of the anaemia is assumed to be due to iron deficiency [3De Benoist B, Cogswell M, Egli I. Worldwide prevalence of anaemia 1993-2005; WHO Global Database of anaemia. https://stacks.cdc.gov/view/cdc/5351]. Africa has more number of women with anemia followed by South and Southeast Asia. Member States have asked for direction from the World Health Organization (WHO) on the effectiveness and safety of daily iron and folic acid supplementation in pregnant women as a public health measure to improve pregnancy outcomes in support of their efforts to achieve the Sustainable Development Goals (SDGs). The WHO also advocates daily Iron Folic Acid (IFA) supplementation (30-60 mg iron, 0.4 g folic acid) initiation as early as possible and continued throughout pregnancy as an important intervention to address the risk of maternal anaemia and low-birthweight babies [4World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience 2016.https://apps.who.int/iris/bitstream /handle/ 10665/250796/9789241549912-eng.pdf].
Pregnant women in India continue to face high anemia rates [8World Health Organization. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. https://apps.who.int/ iris/ bitstream/ handle/ 10665/43894/9789241596657_eng. pdf, 9Suryanarayana R, Santhuram AN, Chandrappa M, Shivajirao P, Rangappa SS. Prevalence of anemia among pregnant women in rural population of Kolar district. Int J Med Sci Public Health 2016; 5(3): 454-8. [http://dx.doi.org/10.5455/ijmsph.2016.2307201575] ]. In India, anemia affects 50% of pregnant women, adolescent girls and children [10Kalaivani K. Prevalence & consequences of anaemia in pregnancy. Indian J Med Res 2009; 130(5): 627-33. [PMID: 20090119] ]. Anemia puts women at greater risk of morbidity, mortality, postpartum hemorrhage, and poor birth outcomes, as well as preterm birth and low birth weight due to poor intrauterine growth. Anemia accounts for 40% of maternal deaths in India [10Kalaivani K. Prevalence & consequences of anaemia in pregnancy. Indian J Med Res 2009; 130(5): 627-33. [PMID: 20090119] ]. In the case of India, IFA consumption has been low among pregnant women in spite of free distribution of IFA supplementations, especially during ANC visits. In India, the distribution of IFA supplements to pregnant women through ANC is the largest programme with the greatest potential for helping to achieve the World Health Assembly goal for 2025. But the major concern among policymakers and researchers has been poor adherence to the supplement among pregnant women. However, we tend to think that given the severity of the problem, there is no investigation on the adherence issue. Based on anecdotal evidences, we understand that the pregnant women who attend ANC do not receive recommended 100 IFA supplements in their first visit mainly because of stock-outs and ineffective management. Hence, an attempt is made in this paper to understand whether IFA consumption by pregnant women in India largely a distribution problem of IFA supplements through ANC.
2. MATERIALS AND METHODS
In India, District Level Household Survey-4 (DLHS-4), is the only source of information on the number of IFA supplements distributed and consumed by pregnant women. It was a community-based cross-sectional survey conducted in 19 states and 2 Union Territories (UTs) of India from June to December 2013. It is the fourth district-level survey implemented by the Ministry of Health and Family Welfare (MoHFW), Government of India and directed by nodal agency, the International Institute for Population Sciences (IIPS), Mumbai. In the survey, the representative sample of the total of 319,695 women of reproductive age, 15-49, were interviewed in their communities. Out of the interviewed women, 88,487 women reported that they were pregnant after January 1, 2008, and among these, 86,683 women experienced live-birth. The pregnant women with live birth or stillbirth in the previous five years were asked the following questions: (i) ‘How many times you received antenatal check-up during last pregnancy?’(ii) ‘How many IFA tablets/bottles did you receive/purchase during the last pregnancy?’ (iii) ‘During the last pregnancy, for how many days and how much did you take the Iron Folic Acid (IFA) tablets/syrup bottles?’
Pregnant Women in India who attend ANC, receive either IFA tablets or syrup based on their preference. For the analysis, IFA syrup was converted into tablets with the assumption that two bottles of syrup are equivalent to 100 tablets. This has been a common practice among researchers using DLHS data [1111 Ministry of Health and Family welfare, Government of India, International Institute for Population Science, Deonar, Mumbai( 2014) District Level Household and Facility Survey (DLHS 4) 2012-2013 2014.http://rchiips.org/ DLHS-4.html]. In order to understand the association between distribution and consumption among those who attend ANCs, bivariate and tri-variate analyses were conducted along with the correlation coefficient using the Statistical Package for Social Science, version – 20.
ANC visits by the pregnant women by Indian States and Union Territories (UTs) are presented in Table 1. ANC visits are particularly low in Nagaland (37%), Meghalaya (53%) and Arunachal Pradesh (56%) of the pregnant women. On the other hand, Telangana, Maharashtra, Kerala, Chhattisgarh, Sikkim, Andaman and Nicobar, Goa, West Bengal, Andhra Pradesh and Karnataka, more than 70% of the pregnant women attended 3 or more ANC. In addition, more than 60% of the pregnant women in the States of Manipur, Mizoram, Tripura, and Pondicherry attended three or more ANC.
Table 1 The percentage of ANC visits among currently pregnant women (aged 15-49) by States in India, 2012-13.
Table 2 Percentage IFA supplements received during ANC visits among pregant women (aged 15-49), by states in India, 2012-13.
Table 2 presents the distribution of the number of IFA supplements to pregnant women during their ANC visits in the States and UTs of India. In Goa, around half of the currently married women received 100 or more IFA supplements though these women didn’t visit ANC clinics. But none of the women received IFA supplements in Chhattisgarh if they did not attend ANC. Similarly, nearly one-third of currently married women in the UTs, Andaman and Nicobar, and the state of Himachal Pradesh received 100 or more IFA supplements privately. On the other hand, about one-fourth of the women in West Bengal, Kerala and Mizoram received 100 or more IFA supplements from private providers. Pregnant women from the other States, for 100 or more IFA supplements, they have to depend upon government free distribution through ANC. Among those women who attended one or two ANCs, only in Goa all women received 100 or more tablets. In case of Kerala and Himachal Pradesh around half of the women received 100 or more IFA supplements if they attend one or two ANCs; followed by 43.4% and 43.7% of the women in Sikkim and Tripura. About one fourth in Punjab and Telangana received 100 or more IFA in their first two ANC visits. For the remaining States in India, the distribution of 100 or more IFA supplements to pregnant women was low among those who attend less than 3 ANC.
Table 2 also shows that during three or more ANC visits, more than 70% of pregnant women of Kerala and, Goa states received 100 or more IFA supplements. In Tripura, Nagaland and Arunachal Pradesh, less than 30% of pregnant women received 100 or more IFA supplements even after attending ANCs for more than three times. Around one-third of pregnant women in Punjab, and Haryana, who attended ANCs three or more times, received 100 or more IFA supplements (Table 2).
Table 3 shows the distribution of pregnant women who received IFA supplements by their consumption patterns. In almost all the states except Chhattisgarh, more than 75% of the pregnant women consumed 100 or more IFA supplements when they received 100 or more IFA supplements through private providers. Similar is the case even among those women who received 100 or more IFA supplements through 1 or 2 ANC attendance with the exception of small states and UTs such as Arunachal Pradesh (60%), Meghalaya (67%), Pondicherry (57%) and Andaman and Nicobar (0%). The consumption of IFA supplements among pregnant women gets better than 75% if they receive 100 or more supplements only after attending three or more ANCs with the exception of Arunachal Pradesh (68%), West Bengal (74%) and Andaman Nicobar (74%). It is noticed that among the 21 States and UTs considered, women from 12 states and UTs consume more
than 90% of the supplements when they receive 100 or more supplements after attending 3 or more ANCs. Similarly, women from 17 states and UTs consume more than 80% of the supplements when they receive 100 or more IFA supplements through 3 or more ANC attendance.
Table 3 Percentage of IFA supplements consumed among pregant women (aged 15-49) who have received IFA supplements during ANC visits by states, India, 2012-13.
IFA supplement supply is a public health issue in India and varies significantly across the states of India. Data on IFA programme reporting by state-wise are often absent. The programme monitoring of IFA distribution and consumption of the supplements by the women is not possible unless pregnant women supply information on the consumption of supplements that must be taken daily. Attempts at estimating coverage are consequently often made indirectly using the number of ANC visits and compliance with IFA distribution protocols and the pregnant women’s compliance with IFA consumption protocols. Given the lack of monitoring capacity and coverage data for IFA supplementation programmes, our contribution in the current paper is to provide a relationship between IFA distribution and consumption by using population-based DLHS-4 data to draw the strengths and weaknesses of ANC-based IFA distribution and consumption.
Despite the fact that ANC is used as the main platform for IFA supplement distribution to pregnant women in India, it's full (at least four or more visits) ANC coverage nationally is only 59% during their last pregnancy [12Ministry of Health and Family Welfare, Government of India. India National Family Health Survey (NFHS-4) 2015–16 2017.]. Low ANC visits are observed in the northeast Indian states. The program needs to improve ANC coverage, distribution of IFA supplements and may involve the foremost cultural change towards the consumption of the supplements. These are generally long-term propositions. Whether the coverage of ANC is low due to women’s lack of physical access to care or because they do not value ANC (for whatever reason), our analysis showed that there is a fundamental health system problem [12Ministry of Health and Family Welfare, Government of India. India National Family Health Survey (NFHS-4) 2015–16 2017.]. It seems Iron/Folic Acid supplementation is affected by supply-related aspects than poor adherence to the supplement by the women. It is surprising that even after attending one or two ANCs, less than half (in many states, much less than half) of the pregnant women received 100 or more IFA supplements except in the case of Himachal Pradesh, Goa and Kerala. However, Himachal Pradesh and Kerala achieved barely 50%, while Goa is a small sate and may be easier to manage the programme [13Mithra P, Unnikrishnan B, Rekha T, et al. Compliance with iron-folic acid (IFA) therapy among pregnant women in an urban area of south India. Afr Health Sci 2013; 13(4): 880-5. [http://dx.doi.org/10.4314/ahs.v13i4.3] [PMID: 24940307] , 14Rani M, Bonu S, Harvey S. Differentials in the quality of antenatal care in India. Int J Qual Health Care 2008; 20(1): 62-71. [http://dx.doi.org/10.1093/intqhc/mzm052] [PMID: 18024998] ].
In the case of African countries, it was found that when pregnant women received at least 90 Iron-Folic Acid supplements through antenatal care, the risk of neonatal mortality decreased by 34% [15Titaley CR, Dibley MJ, Roberts CL, Agho K. Combined iron/folic acid supplements and malaria prophylaxis reduce neonatal mortality in 19 sub-Saharan African countries. Am J Clin Nutr 2010; 92(1): 235-43. [http://dx.doi.org/10.3945/ajcn.2009.29093] [PMID: 20504976] , 16Nisar YB, Dibley MJ. Earlier initiation and use of a greater number of iron-folic acid supplements during pregnancy prevents early neonatal deaths in Nepal and Pakistan. PLoS One 2014; 9(11)e112446 [http://dx.doi.org/10.1371/journal.pone.0112446] [PMID: 25398011] ]. In South Asian countries, the prevalence of anaemia is the highest in the World, and India tops this list of countries, possibly leading to a high risk for neonatal and maternal mortality [17World Health Organization. World Food Programme, & United Nations Children’s Fund.Preventing and controlling micronutrient deficiencies in populations Affected by an emergency 2007.]. In India, according to DLHS-3, less than half of the mothers consumed 100 IFA tablets among those who received during their ANC visits [18Ministry of Health and Family Welfare Government of India. consumption of IFA tablet, State fact sheet District Level Household and Facility Survey 2007-08. http://rchiips.org/ state-fact-sheet-rch3.html2018.]. The current analysis using the latest DLHS data shows that there is a very high correlation (0.95) between IFA supplements received and consumed by pregnant women. This implies that in the Indian States ANC based IFA distribution is a major stumbling issue. Therefore, the public distribution may have to confront the monumental task of improving IFA supplementation program, and it requires strengthening the entire health system at the state level.
Additionally, evidences have shown that among the rural and lower socio-economic groups, there were associations between caste and the use of ANC as well as service components of ANC provided [14Rani M, Bonu S, Harvey S. Differentials in the quality of antenatal care in India. Int J Qual Health Care 2008; 20(1): 62-71. [http://dx.doi.org/10.1093/intqhc/mzm052] [PMID: 18024998] , 19Navaneetham K, Dharmalingam A. Utilization of maternal health care services in Southern India. Soc Sci Med 2002; 55(10): 1849-69. [http://dx.doi.org/10.1016/S0277-9536(01)00313-6] [PMID: 12383469] ]. These disadvantaged groups tend to receive their IFA supplements free from the Government through ANC attendance. It may be because of poverty, and these women tend to work while pregnant, coupled with high illiteracy and lack of awareness, full ANC (at least 4 ANCs) attendance can be very low. Moreover, it may not be possible for pregnant women to attend more than one or two ANCs, especially if the facility for ANC attendance is not in their usual place of residence. Our discussion with the front-line workers suggests that during the first ANC attendance, the women do not receive the recommended 100 IFA supplements due to lack of stock and untimely supply. The argument that the compliance of consumption is very low among these women is not correct. As our results indicate, nearly 80% of women do consume if they receive 100 or more IFA supplements.
It seems distribution is a problem in the consumption of Iron-Folic Acid supplements by pregnant women in India than the commonly perceived problem of adherence to the supplements. The consumption of IFA, it seems, is not necessarily affected due to some social reasons like false belief and lack of awareness as hypothesized by policymakers and programmers. It appears only a small percentage of pregnant women receive IFA supplements through private providers, and the majority of them depend upon the public distribution of the supplements through ANC attendance. Moreover, the attendance of 3 or more ANCs among pregnant women, especially in rural areas with low socioeconomic status can be a challenge. Anecdotal evidences suggest that during the first ANC attendance, the women do not receive the recommended 100 IFA supplements due to lack of stock and untimely supply. Hence, governments should distribute the recommended 100 IFA supplements to the women in their 1st ANC attendance to address anaemia, and in turn, morbidity and mortality among pregnant women and newborn babies. If necessary, the service component should be strengthened at the state level, and the capacity building training should be given from time to time to the front-line workers and health care providers.
Rajeshwari A. Biradar led the literature search, analysis and interpretation, and manuscript writing along with the incorporation of feedback and comments from co-author. Shiva S. Halli has examined the results, tables, and contributed to the study design and finalized the manuscript.
ETHICS APPROVAL AND CONSENT TO PARTICIPATE
HUMAN AND ANIMAL RIGHTS
CONSENT FOR PUBLICATION
AVAILABILITY OF DATA AND MATERIALS
The raw data used in this research is publicly available large-scale health data with permission from International Institute for Population Sciences, Mumbai
CONFLICT OF INTEREST
The authors declare no conflict of interest, financial or otherwise.
We are thankful to the Ministry of Health and Family Welfare, India, and to the nodal agency (International Institute for Population Sciences, Mumbai) for providing us DLHS-4 data for this paper.
Suryanarayana R, Santhuram AN, Chandrappa M, Shivajirao P, Rangappa SS. Prevalence of anemia among pregnant women in rural population of Kolar district. Int J Med Sci Public Health 2016; 5(3): 454-8. [http://dx.doi.org/10.5455/ijmsph.2016.2307201575]
Kalaivani K. Prevalence & consequences of anaemia in pregnancy. Indian J Med Res 2009; 130(5): 627-33. [PMID: 20090119]
11 Ministry of Health and Family welfare, Government of India, International Institute for Population Science, Deonar, Mumbai( 2014) District Level Household and Facility Survey (DLHS 4) 2012-2013 2014.http://rchiips.org/ DLHS-4.html
Ministry of Health and Family Welfare, Government of India. India National Family Health Survey (NFHS-4) 2015–16 2017.
Mithra P, Unnikrishnan B, Rekha T, et al. Compliance with iron-folic acid (IFA) therapy among pregnant women in an urban area of south India. Afr Health Sci 2013; 13(4): 880-5. [http://dx.doi.org/10.4314/ahs.v13i4.3] [PMID: 24940307]